Hepatoprotective effect of blue honeysuckle on rat hypothyroidism

Woo Yeol Lee; Seong Joon Yi; Sungho Yun; Tae Ho Oh; Hong Tae Kim; Mee Kyung Lim; Keun Woo Lee

doi:10.17555/jvc.2017.12.34.6.404

Hepatoprotective effect of blue honeysuckle on rat hypothyroidism

Woo Yeol Lee, Seong Joon Yi, Sungho Yun, Tae Ho Oh, Hong Tae Kim, Mee Kyung Lim, Keun Woo Lee

Department of Veterinary Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

This study was to determine whether blue honeysuckle lyophilized concentrated powder (BH) has positive effects on hypothyroidism and related liver damage in propylthiouracil-induced Hypothyroidism. Levothyroxine (LT4)-treated group was administrated by intraperitoneal injection with LT4, while BH or Flos Lonicerae lyophilized aqueous extract (LF)-treated groups were orally administrated for 42 days which two weeks pri or to PTU injection. The changes in organ weight, serum AST & ALT, serum lipid level, liver defense system were measured and the histopathology of the liver was observed. The oral administrations of 125, 250, and 500 mg/kg of BH showed favorable effects compared to LF on hypothyroidism-related liver damages through the enhance antioxidant defense system.

Original language	English
Pages (from-to)	404-409
Number of pages	6
Journal	Journal of Veterinary Clinics
Volume	34
Issue number	6
DOIs	https://doi.org/10.17555/jvc.2017.12.34.6.404
State	Published - Dec 2017

Keywords

Blue honeysuckle
Hypothyroidism
Levothyroxine
Liver
Rat

Access to Document

10.17555/jvc.2017.12.34.6.404

Cite this

@article{6835a958541645978715903584b7e2fc,

title = "Hepatoprotective effect of blue honeysuckle on rat hypothyroidism",

abstract = "This study was to determine whether blue honeysuckle lyophilized concentrated powder (BH) has positive effects on hypothyroidism and related liver damage in propylthiouracil-induced Hypothyroidism. Levothyroxine (LT4)-treated group was administrated by intraperitoneal injection with LT4, while BH or Flos Lonicerae lyophilized aqueous extract (LF)-treated groups were orally administrated for 42 days which two weeks pri or to PTU injection. The changes in organ weight, serum AST \& ALT, serum lipid level, liver defense system were measured and the histopathology of the liver was observed. The oral administrations of 125, 250, and 500 mg/kg of BH showed favorable effects compared to LF on hypothyroidism-related liver damages through the enhance antioxidant defense system.",

keywords = "Blue honeysuckle, Hypothyroidism, Levothyroxine, Liver, Rat",

author = "Lee, \{Woo Yeol\} and Yi, \{Seong Joon\} and Sungho Yun and Oh, \{Tae Ho\} and Kim, \{Hong Tae\} and Lim, \{Mee Kyung\} and Lee, \{Keun Woo\}",

year = "2017",

month = dec,

doi = "10.17555/jvc.2017.12.34.6.404",

language = "English",

volume = "34",

pages = "404--409",

journal = "Journal of Veterinary Clinics",

issn = "1598-298X",

publisher = "Korean Society of Veterinary Clinics",

number = "6",

}

TY - JOUR

T1 - Hepatoprotective effect of blue honeysuckle on rat hypothyroidism

AU - Lee, Woo Yeol

AU - Yi, Seong Joon

AU - Yun, Sungho

AU - Oh, Tae Ho

AU - Kim, Hong Tae

AU - Lim, Mee Kyung

AU - Lee, Keun Woo

PY - 2017/12

Y1 - 2017/12

N2 - This study was to determine whether blue honeysuckle lyophilized concentrated powder (BH) has positive effects on hypothyroidism and related liver damage in propylthiouracil-induced Hypothyroidism. Levothyroxine (LT4)-treated group was administrated by intraperitoneal injection with LT4, while BH or Flos Lonicerae lyophilized aqueous extract (LF)-treated groups were orally administrated for 42 days which two weeks pri or to PTU injection. The changes in organ weight, serum AST & ALT, serum lipid level, liver defense system were measured and the histopathology of the liver was observed. The oral administrations of 125, 250, and 500 mg/kg of BH showed favorable effects compared to LF on hypothyroidism-related liver damages through the enhance antioxidant defense system.

AB - This study was to determine whether blue honeysuckle lyophilized concentrated powder (BH) has positive effects on hypothyroidism and related liver damage in propylthiouracil-induced Hypothyroidism. Levothyroxine (LT4)-treated group was administrated by intraperitoneal injection with LT4, while BH or Flos Lonicerae lyophilized aqueous extract (LF)-treated groups were orally administrated for 42 days which two weeks pri or to PTU injection. The changes in organ weight, serum AST & ALT, serum lipid level, liver defense system were measured and the histopathology of the liver was observed. The oral administrations of 125, 250, and 500 mg/kg of BH showed favorable effects compared to LF on hypothyroidism-related liver damages through the enhance antioxidant defense system.

KW - Blue honeysuckle

KW - Hypothyroidism

KW - Levothyroxine

KW - Liver

KW - Rat

UR - http://www.scopus.com/inward/record.url?scp=85044465214&partnerID=8YFLogxK

U2 - 10.17555/jvc.2017.12.34.6.404

DO - 10.17555/jvc.2017.12.34.6.404

M3 - Article

AN - SCOPUS:85044465214

SN - 1598-298X

VL - 34

SP - 404

EP - 409

JO - Journal of Veterinary Clinics

JF - Journal of Veterinary Clinics

IS - 6

ER -

Hepatoprotective effect of blue honeysuckle on rat hypothyroidism

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this