TY - JOUR
T1 - Hepatoprotective effects of ilex paraguariensis st. Hilaire (yerba mate) extract in rats
AU - Jang, Seung Hee
AU - Hossain, Md Akil
AU - Lee, Jong Suk
AU - Reza, Md Ahsanur
AU - Lee, Sam Pin
AU - Kang, Jeongwoo
AU - Park, Seung Chun
N1 - Publisher Copyright:
© 2018, National Institute of Science Communication and Information Resources (NISCAIR). All rights reserved.
PY - 2018/10
Y1 - 2018/10
N2 - Ilex paraguariensis St. Hilaire has been revealed as an antioxidant, diuretic, hypocholesterolemic, and obesity preventive agent. The objective of the present study was to investigate the hepatoprotective effect of Ilex paraguariensis 70 % ethanol extract (IPEE) against carbon tetrachloride-induced liver injury in an animal model. IPEE (200 and 400 mg/kg/day) were administered to rats for 7 days prior to a single dose of CCl4. Organs were collected for biochemical, histological, and molecular study after 24 h of CCl4 application. Chromatographic analyses of IPEE were accomplished. The GGT, ALP, ALT and AST in CCl4-treated control were 9, 32, 401 and 168 % increased, correspondingly than in non-treated control. The SOD, GSH and GPx levels in IPEE-pre-treated rats were similar to non-toxicated control, but were seriously affected in CCl4-treated control. The IPEE pre-treatment reduced hepatic lesions and necrosis, and expressions of PPARα and CYP4A2 were recovered about 48 % by 400 mg/kg/day of IPEE-pre-treatment. We found 6 major compounds, including cynarine and chlorogenic acid, and the extract was appeared to be non-toxic in acute toxicity study. This study indicates the protective effect of IPEE against CCl4-associated liver injury by attributing its control on PPARα, CYP4A2 regulation, and thereby it could be an opportunistic agent.
AB - Ilex paraguariensis St. Hilaire has been revealed as an antioxidant, diuretic, hypocholesterolemic, and obesity preventive agent. The objective of the present study was to investigate the hepatoprotective effect of Ilex paraguariensis 70 % ethanol extract (IPEE) against carbon tetrachloride-induced liver injury in an animal model. IPEE (200 and 400 mg/kg/day) were administered to rats for 7 days prior to a single dose of CCl4. Organs were collected for biochemical, histological, and molecular study after 24 h of CCl4 application. Chromatographic analyses of IPEE were accomplished. The GGT, ALP, ALT and AST in CCl4-treated control were 9, 32, 401 and 168 % increased, correspondingly than in non-treated control. The SOD, GSH and GPx levels in IPEE-pre-treated rats were similar to non-toxicated control, but were seriously affected in CCl4-treated control. The IPEE pre-treatment reduced hepatic lesions and necrosis, and expressions of PPARα and CYP4A2 were recovered about 48 % by 400 mg/kg/day of IPEE-pre-treatment. We found 6 major compounds, including cynarine and chlorogenic acid, and the extract was appeared to be non-toxic in acute toxicity study. This study indicates the protective effect of IPEE against CCl4-associated liver injury by attributing its control on PPARα, CYP4A2 regulation, and thereby it could be an opportunistic agent.
KW - Antioxidant activity
KW - Hepatoprotective activity
KW - Ilex paraguariensis
KW - Oxidative stress
KW - Yerba mate
UR - http://www.scopus.com/inward/record.url?scp=85053473814&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:85053473814
SN - 0972-5938
VL - 17
SP - 707
EP - 715
JO - Indian Journal of Traditional Knowledge
JF - Indian Journal of Traditional Knowledge
IS - 4
ER -
