TY - JOUR
T1 - Hepatoprotective effects of polysaccharides isolated from Phellinus gilvus against carbon tetrachloride-induced liver injury in rats
AU - Park, Seung Chun
AU - Cheon, Yong Pil
AU - Son, Wha Young
AU - Rhee, Man Hee
AU - Kim, Tae Wan
AU - Song, Jae Chan
AU - Kim, Kil Soo
PY - 2009
Y1 - 2009
N2 - Phellinus gilvus (PG) is a widely used mushroom for health promotion. We studied the hepatoprotective effect of the polysaccharide aqueous extract of PG (PGP) against carbon tetrachloride (CCl 4)-induced liver injury in rats. Sprague Dawley rats were divided into 5 groups: Normal control, CCl 4 control, PGP 50, 100, and 200 mg/kg + CCl 4. The levels of serum biochemical parameters, liver lipid peroxide and antioxidant enzymes, and histological appearances were evaluated. The CCl 4-induced increments of alanine aminotransferase, asparate aminotransferase, and alkaline phosphatase levels in serum were significantly decreased by PGP-pretreatments. The PGP dose-dependently decreased hepatic malondialdehyde formations in CCl 4-treatment groups. Hepatic antioxidant enzymes (superoxide dismutase, catalase, and glutathione peroxidase) were elevated by PGP in CCl 4-treatment groups. Histopathological evaluation of liver showed that the loss of hepatocytes, fatty changes, swelling and extensive necrosis of hepatocytes in centrilobular regions of the CCl 4-treated rats were ameliorated by PGP pretreatment. The PGP has hepatoprotective and antioxidative effects in CCl 4-induced liver injury of rat.
AB - Phellinus gilvus (PG) is a widely used mushroom for health promotion. We studied the hepatoprotective effect of the polysaccharide aqueous extract of PG (PGP) against carbon tetrachloride (CCl 4)-induced liver injury in rats. Sprague Dawley rats were divided into 5 groups: Normal control, CCl 4 control, PGP 50, 100, and 200 mg/kg + CCl 4. The levels of serum biochemical parameters, liver lipid peroxide and antioxidant enzymes, and histological appearances were evaluated. The CCl 4-induced increments of alanine aminotransferase, asparate aminotransferase, and alkaline phosphatase levels in serum were significantly decreased by PGP-pretreatments. The PGP dose-dependently decreased hepatic malondialdehyde formations in CCl 4-treatment groups. Hepatic antioxidant enzymes (superoxide dismutase, catalase, and glutathione peroxidase) were elevated by PGP in CCl 4-treatment groups. Histopathological evaluation of liver showed that the loss of hepatocytes, fatty changes, swelling and extensive necrosis of hepatocytes in centrilobular regions of the CCl 4-treated rats were ameliorated by PGP pretreatment. The PGP has hepatoprotective and antioxidative effects in CCl 4-induced liver injury of rat.
KW - Carbon tetrachloride
KW - Hepatoprotective effect
KW - Phellinus gilvus polysaccharide
UR - https://www.scopus.com/pages/publications/84863235007
U2 - 10.5487/TR.2009.25.1.029
DO - 10.5487/TR.2009.25.1.029
M3 - Article
AN - SCOPUS:84863235007
SN - 1976-8257
VL - 25
SP - 29
EP - 33
JO - Toxicological Research
JF - Toxicological Research
IS - 1
ER -