Hepatoprotective effects of vicenin-2 and scolymoside through the modulation of inflammatory pathways

In Chul Lee; Jong Sup Bae

doi:10.1007/s11418-019-01348-x

Hepatoprotective effects of vicenin-2 and scolymoside through the modulation of inflammatory pathways

In Chul Lee, Jong Sup Bae

Seowon University

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

The aim of this study was to investigate the effects of two structurally related flavonoids found in Cyclopia subternata, vicenin-2 (VCN) and scolymoside (SCL) on lipopolysaccharide (LPS)-induced liver failure in mice and to elucidate underlying mechanisms. Mice were treated intravenously with VCN or SCL at 12 h after LPS treatment. LPS significantly increased mortality, serum levels of alanine transaminase, aspartate transaminase, and inflammatory cytokines, and toll-like receptor 4 (TLR4) protein expression; these effects of LPS were inhibited by VCN or SCL. It also attenuated the LPS-induced activation of myeloid differentiation primary response gene 88 and TLR-associated activator of interferon-dependent signaling pathways of the TLR system. Our results suggest that VCN or SCL protects against LPS-induced liver damage by inhibiting the TLR-mediated inflammatory pathway, indicating its potential to treat liver diseases.

Original language	English
Pages (from-to)	90-97
Number of pages	8
Journal	Journal of Natural Medicines
Volume	74
Issue number	1
DOIs	https://doi.org/10.1007/s11418-019-01348-x
State	Published - 1 Jan 2020

Keywords

Lipopolysaccharide
Liver failure
Scolymoside
Toll-like receptor
Vicenin-2

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title = "Hepatoprotective effects of vicenin-2 and scolymoside through the modulation of inflammatory pathways",

abstract = "The aim of this study was to investigate the effects of two structurally related flavonoids found in Cyclopia subternata, vicenin-2 (VCN) and scolymoside (SCL) on lipopolysaccharide (LPS)-induced liver failure in mice and to elucidate underlying mechanisms. Mice were treated intravenously with VCN or SCL at 12 h after LPS treatment. LPS significantly increased mortality, serum levels of alanine transaminase, aspartate transaminase, and inflammatory cytokines, and toll-like receptor 4 (TLR4) protein expression; these effects of LPS were inhibited by VCN or SCL. It also attenuated the LPS-induced activation of myeloid differentiation primary response gene 88 and TLR-associated activator of interferon-dependent signaling pathways of the TLR system. Our results suggest that VCN or SCL protects against LPS-induced liver damage by inhibiting the TLR-mediated inflammatory pathway, indicating its potential to treat liver diseases.",

keywords = "Lipopolysaccharide, Liver failure, Scolymoside, Toll-like receptor, Vicenin-2",

author = "Lee, {In Chul} and Bae, {Jong Sup}",

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doi = "10.1007/s11418-019-01348-x",

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T1 - Hepatoprotective effects of vicenin-2 and scolymoside through the modulation of inflammatory pathways

AU - Lee, In Chul

AU - Bae, Jong Sup

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N2 - The aim of this study was to investigate the effects of two structurally related flavonoids found in Cyclopia subternata, vicenin-2 (VCN) and scolymoside (SCL) on lipopolysaccharide (LPS)-induced liver failure in mice and to elucidate underlying mechanisms. Mice were treated intravenously with VCN or SCL at 12 h after LPS treatment. LPS significantly increased mortality, serum levels of alanine transaminase, aspartate transaminase, and inflammatory cytokines, and toll-like receptor 4 (TLR4) protein expression; these effects of LPS were inhibited by VCN or SCL. It also attenuated the LPS-induced activation of myeloid differentiation primary response gene 88 and TLR-associated activator of interferon-dependent signaling pathways of the TLR system. Our results suggest that VCN or SCL protects against LPS-induced liver damage by inhibiting the TLR-mediated inflammatory pathway, indicating its potential to treat liver diseases.

AB - The aim of this study was to investigate the effects of two structurally related flavonoids found in Cyclopia subternata, vicenin-2 (VCN) and scolymoside (SCL) on lipopolysaccharide (LPS)-induced liver failure in mice and to elucidate underlying mechanisms. Mice were treated intravenously with VCN or SCL at 12 h after LPS treatment. LPS significantly increased mortality, serum levels of alanine transaminase, aspartate transaminase, and inflammatory cytokines, and toll-like receptor 4 (TLR4) protein expression; these effects of LPS were inhibited by VCN or SCL. It also attenuated the LPS-induced activation of myeloid differentiation primary response gene 88 and TLR-associated activator of interferon-dependent signaling pathways of the TLR system. Our results suggest that VCN or SCL protects against LPS-induced liver damage by inhibiting the TLR-mediated inflammatory pathway, indicating its potential to treat liver diseases.

KW - Lipopolysaccharide

KW - Liver failure

KW - Scolymoside

KW - Toll-like receptor

KW - Vicenin-2

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Hepatoprotective effects of vicenin-2 and scolymoside through the modulation of inflammatory pathways

Abstract

Keywords

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