Hepatoprotective effects of vicenin-2 and scolymoside through the modulation of inflammatory pathways

In Chul Lee, Jong Sup Bae

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

The aim of this study was to investigate the effects of two structurally related flavonoids found in Cyclopia subternata, vicenin-2 (VCN) and scolymoside (SCL) on lipopolysaccharide (LPS)-induced liver failure in mice and to elucidate underlying mechanisms. Mice were treated intravenously with VCN or SCL at 12 h after LPS treatment. LPS significantly increased mortality, serum levels of alanine transaminase, aspartate transaminase, and inflammatory cytokines, and toll-like receptor 4 (TLR4) protein expression; these effects of LPS were inhibited by VCN or SCL. It also attenuated the LPS-induced activation of myeloid differentiation primary response gene 88 and TLR-associated activator of interferon-dependent signaling pathways of the TLR system. Our results suggest that VCN or SCL protects against LPS-induced liver damage by inhibiting the TLR-mediated inflammatory pathway, indicating its potential to treat liver diseases.

Original languageEnglish
Pages (from-to)90-97
Number of pages8
JournalJournal of Natural Medicines
Volume74
Issue number1
DOIs
StatePublished - 1 Jan 2020

Keywords

  • Lipopolysaccharide
  • Liver failure
  • Scolymoside
  • Toll-like receptor
  • Vicenin-2

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