Heterologous expression of fission yeast heavy metal tolerance factor 1, SpHMT1, confers increased sensitivity to copper in budding yeast

Sangman Lee

doi:10.3839/jksabc.2010.098

Heterologous expression of fission yeast heavy metal tolerance factor 1, SpHMT1, confers increased sensitivity to copper in budding yeast

Sangman Lee

School of Applied Bioscience

Research output: Contribution to journal › Article › peer-review

Abstract

Heterologous expression of fission yeast Schizosaccharomyces pombe heavy metal tolerance factor 1 (SpHMT1) confers increased tolerance to Cd but sensitivity to Cu in budding yeast. Due to its sensitivity to Cu, SpHMT1 cannot be used in bioremediation of Cd in Cu-contaminated sites. Thus, in the present study we attempted to solve this problem by expressing SpHMT1 in Cu-resistant yeast mutants.

Original language	English
Pages (from-to)	647-651
Number of pages	5
Journal	Journal of Applied Biological Chemistry
Volume	53
Issue number	5
DOIs	https://doi.org/10.3839/jksabc.2010.098
State	Published - 2010

Keywords

Bioremediation
Cadmium
Copper
Heavy metal tolerance factor
Yeast

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10.3839/jksabc.2010.098

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abstract = "Heterologous expression of fission yeast Schizosaccharomyces pombe heavy metal tolerance factor 1 (SpHMT1) confers increased tolerance to Cd but sensitivity to Cu in budding yeast. Due to its sensitivity to Cu, SpHMT1 cannot be used in bioremediation of Cd in Cu-contaminated sites. Thus, in the present study we attempted to solve this problem by expressing SpHMT1 in Cu-resistant yeast mutants.",

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AB - Heterologous expression of fission yeast Schizosaccharomyces pombe heavy metal tolerance factor 1 (SpHMT1) confers increased tolerance to Cd but sensitivity to Cu in budding yeast. Due to its sensitivity to Cu, SpHMT1 cannot be used in bioremediation of Cd in Cu-contaminated sites. Thus, in the present study we attempted to solve this problem by expressing SpHMT1 in Cu-resistant yeast mutants.

KW - Bioremediation

KW - Cadmium

KW - Copper

KW - Heavy metal tolerance factor

KW - Yeast

UR - https://www.scopus.com/pages/publications/78549265556

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DO - 10.3839/jksabc.2010.098

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VL - 53

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EP - 651

JO - Journal of Applied Biological Chemistry

JF - Journal of Applied Biological Chemistry

IS - 5

ER -

Heterologous expression of fission yeast heavy metal tolerance factor 1, SpHMT1, confers increased sensitivity to copper in budding yeast

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