TY - JOUR
T1 - High-Quantum-Yield Ultrasmall Ln2O3 (Ln = Eu, Tb, or Dy) Nanoparticle Colloids in Aqueous Media Obtained via Photosensitization
AU - Tegafaw, Tirusew
AU - Liu, Ying
AU - Ho, Son Long
AU - Liu, Shuwen
AU - Ahmad, Mohammad Yaseen
AU - Al Saidi, Abdullah Khamis Ali
AU - Zhao, Dejun
AU - Ahn, Dabin
AU - Nam, Hyunji
AU - Chae, Weon Sik
AU - Nam, Sung Wook
AU - Chang, Yongmin
AU - Lee, Gang Ho
N1 - Publisher Copyright:
© 2023 American Chemical Society.
PY - 2023/10/31
Y1 - 2023/10/31
N2 - Fluorescent nanoparticles used in biomedical applications should be stable in their colloidal form in aqueous media and possess a high quantum yield (QY). We report ultrasmall Ln2O3 (Ln = Eu, Tb, or Dy) nanoparticle colloids with high QYs in aqueous media. The nanoparticles are grafted with hydrophilic and biocompatible poly(acrylic acid) (PAA) to ensure colloidal stability and biocompatibility and with organic photosensitizer 2,6-pyridinedicarboxylic acid (PDA) for achieving a high QY. The PAA/PDA-Ln2O3 nanoparticle colloids were nearly monodispersed and ultrasmall (particle diameter: ∼2 nm). They exhibited excellent colloidal stability with no precipitation after synthesis (>1.5 years) in aqueous media, very low cellular toxicity, and very high absolute QYs of 87.6, 73.6, and 2.8% for Ln = Eu, Tb, and Dy, respectively. These QYs are the highest reported so far for lanthanides in aqueous media. Therefore, the results suggest their high potential as sensitive optical or imaging probes in biomedical applications.
AB - Fluorescent nanoparticles used in biomedical applications should be stable in their colloidal form in aqueous media and possess a high quantum yield (QY). We report ultrasmall Ln2O3 (Ln = Eu, Tb, or Dy) nanoparticle colloids with high QYs in aqueous media. The nanoparticles are grafted with hydrophilic and biocompatible poly(acrylic acid) (PAA) to ensure colloidal stability and biocompatibility and with organic photosensitizer 2,6-pyridinedicarboxylic acid (PDA) for achieving a high QY. The PAA/PDA-Ln2O3 nanoparticle colloids were nearly monodispersed and ultrasmall (particle diameter: ∼2 nm). They exhibited excellent colloidal stability with no precipitation after synthesis (>1.5 years) in aqueous media, very low cellular toxicity, and very high absolute QYs of 87.6, 73.6, and 2.8% for Ln = Eu, Tb, and Dy, respectively. These QYs are the highest reported so far for lanthanides in aqueous media. Therefore, the results suggest their high potential as sensitive optical or imaging probes in biomedical applications.
UR - http://www.scopus.com/inward/record.url?scp=85175661175&partnerID=8YFLogxK
U2 - 10.1021/acs.langmuir.3c02229
DO - 10.1021/acs.langmuir.3c02229
M3 - Article
C2 - 37856331
AN - SCOPUS:85175661175
SN - 0743-7463
VL - 39
SP - 15338
EP - 15342
JO - Langmuir
JF - Langmuir
IS - 43
ER -