Abstract
Oyster shell is one of the foremost natural sources of calcium and is used as an alternative treatment for osteoporosis. In this study, we demonstrated that zinc-activated nanopowdered oyster shell (Zn-NPOS) effectively reduced bone loss compared with powdered oyster shell (POS) in an ovariectomized rat (OVX) model. As a result of nanosizing, the solubility and bioavailability of the oyster shell were greatly improved, and its effectiveness was further enhanced by zinc activation. Bone analysis indicated greater recovery from ovariectomy-induced bone loss following Zn-NPOS treatment. Moreover, Zn-NPOS treatment resulted in higher bone strength and superior trabecular architecture compared with NPOS and POS treatments. Furthermore, Zn-NPOS showed greater efficiency in increasing bone formation and reducing bone resorption markers. Therefore, nanosizing with zinc activation could be a viable strategy for improving the efficiency of oyster shells used for osteoporosis prevention.
| Original language | English |
|---|---|
| Pages (from-to) | 931-940 |
| Number of pages | 10 |
| Journal | International Journal of Food Sciences and Nutrition |
| Volume | 68 |
| Issue number | 8 |
| DOIs | |
| State | Published - 17 Nov 2017 |
Keywords
- bioavailability
- bone
- Nanopowdered oyster shell
- osteoporosis
- zinc
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