Highly dispersed nanoscale hydroxyapatite on cellulose nanofibers for bone regeneration

Kyohei Yamaguchi; Mayakrishnan Prabakaran; Ma Ke; Xu Gang; Ill Min Chung; In Chul Um; Mayakrishnan Gopiraman; Ick Soo Kim

doi:10.1016/j.matlet.2016.01.010

Highly dispersed nanoscale hydroxyapatite on cellulose nanofibers for bone regeneration

Kyohei Yamaguchi, Mayakrishnan Prabakaran, Ma Ke, Xu Gang, Ill Min Chung, In Chul Um, Mayakrishnan Gopiraman, Ick Soo Kim

Department of Biofibers and Biomaterials Science

Research output: Contribution to journal › Article › peer-review

45 Scopus citations

Abstract

A successful method for fabrication of electrospun hydroxyapatite (HAp) coated cellulose nanofiber scaffold (HAp/CMC) for tissue engineering is reported. The cellulose acetate nanofibers (CANFs) were deacetylated to produce cellulose nanofibers (CNFs) which were subsequently converted to sodium carboxy methyl cellulose (Na-CMC). The Na-CMC nanofibers mat was then coated with HAp for bone regeneration applications. The FTIR results confirmed conversion of CANFs to CNFs and CNFs to Na-CMC. HAp nanocrystal growth was observed in SEM images, with crystal becoming minute and numerous upon increasing HCO3- in the simulated body fluid (SBF) solution. The proliferation of osteoblastic MC3T3-E1cells on HAp-coated CMC nanofiber mat was observed to increase with seeding time. The results confirm suitability of the HAp/CMC nanofiber mat for bone regeneration.

Original language	English
Pages (from-to)	56-61
Number of pages	6
Journal	Materials Letters
Volume	168
DOIs	https://doi.org/10.1016/j.matlet.2016.01.010
State	Published - 1 Apr 2016

Keywords

Bone regeneration
Cellulose nanofibers
Electrospinning
Hydroxyapatite
Nanocomposites

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10.1016/j.matlet.2016.01.010

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title = "Highly dispersed nanoscale hydroxyapatite on cellulose nanofibers for bone regeneration",

abstract = "A successful method for fabrication of electrospun hydroxyapatite (HAp) coated cellulose nanofiber scaffold (HAp/CMC) for tissue engineering is reported. The cellulose acetate nanofibers (CANFs) were deacetylated to produce cellulose nanofibers (CNFs) which were subsequently converted to sodium carboxy methyl cellulose (Na-CMC). The Na-CMC nanofibers mat was then coated with HAp for bone regeneration applications. The FTIR results confirmed conversion of CANFs to CNFs and CNFs to Na-CMC. HAp nanocrystal growth was observed in SEM images, with crystal becoming minute and numerous upon increasing HCO3- in the simulated body fluid (SBF) solution. The proliferation of osteoblastic MC3T3-E1cells on HAp-coated CMC nanofiber mat was observed to increase with seeding time. The results confirm suitability of the HAp/CMC nanofiber mat for bone regeneration.",

keywords = "Bone regeneration, Cellulose nanofibers, Electrospinning, Hydroxyapatite, Nanocomposites",

author = "Kyohei Yamaguchi and Mayakrishnan Prabakaran and Ma Ke and Xu Gang and Chung, {Ill Min} and Um, {In Chul} and Mayakrishnan Gopiraman and Kim, {Ick Soo}",

year = "2016",

month = apr,

day = "1",

doi = "10.1016/j.matlet.2016.01.010",

language = "English",

volume = "168",

pages = "56--61",

journal = "Materials Letters",

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TY - JOUR

T1 - Highly dispersed nanoscale hydroxyapatite on cellulose nanofibers for bone regeneration

AU - Yamaguchi, Kyohei

AU - Prabakaran, Mayakrishnan

AU - Ke, Ma

AU - Gang, Xu

AU - Chung, Ill Min

AU - Um, In Chul

AU - Gopiraman, Mayakrishnan

AU - Kim, Ick Soo

PY - 2016/4/1

Y1 - 2016/4/1

N2 - A successful method for fabrication of electrospun hydroxyapatite (HAp) coated cellulose nanofiber scaffold (HAp/CMC) for tissue engineering is reported. The cellulose acetate nanofibers (CANFs) were deacetylated to produce cellulose nanofibers (CNFs) which were subsequently converted to sodium carboxy methyl cellulose (Na-CMC). The Na-CMC nanofibers mat was then coated with HAp for bone regeneration applications. The FTIR results confirmed conversion of CANFs to CNFs and CNFs to Na-CMC. HAp nanocrystal growth was observed in SEM images, with crystal becoming minute and numerous upon increasing HCO3- in the simulated body fluid (SBF) solution. The proliferation of osteoblastic MC3T3-E1cells on HAp-coated CMC nanofiber mat was observed to increase with seeding time. The results confirm suitability of the HAp/CMC nanofiber mat for bone regeneration.

AB - A successful method for fabrication of electrospun hydroxyapatite (HAp) coated cellulose nanofiber scaffold (HAp/CMC) for tissue engineering is reported. The cellulose acetate nanofibers (CANFs) were deacetylated to produce cellulose nanofibers (CNFs) which were subsequently converted to sodium carboxy methyl cellulose (Na-CMC). The Na-CMC nanofibers mat was then coated with HAp for bone regeneration applications. The FTIR results confirmed conversion of CANFs to CNFs and CNFs to Na-CMC. HAp nanocrystal growth was observed in SEM images, with crystal becoming minute and numerous upon increasing HCO3- in the simulated body fluid (SBF) solution. The proliferation of osteoblastic MC3T3-E1cells on HAp-coated CMC nanofiber mat was observed to increase with seeding time. The results confirm suitability of the HAp/CMC nanofiber mat for bone regeneration.

KW - Bone regeneration

KW - Cellulose nanofibers

KW - Electrospinning

KW - Hydroxyapatite

KW - Nanocomposites

UR - http://www.scopus.com/inward/record.url?scp=84954310995&partnerID=8YFLogxK

U2 - 10.1016/j.matlet.2016.01.010

DO - 10.1016/j.matlet.2016.01.010

M3 - Article

AN - SCOPUS:84954310995

SN - 0167-577X

VL - 168

SP - 56

EP - 61

JO - Materials Letters

JF - Materials Letters

ER -

Highly dispersed nanoscale hydroxyapatite on cellulose nanofibers for bone regeneration

Abstract

Keywords

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