Highly dispersed nanoscale hydroxyapatite on cellulose nanofibers for bone regeneration

Kyohei Yamaguchi; Mayakrishnan Prabakaran; Ma Ke; Xu Gang; Ill Min Chung; In Chul Um; Mayakrishnan Gopiraman; Ick Soo Kim

doi:10.1016/j.matlet.2016.01.010

Highly dispersed nanoscale hydroxyapatite on cellulose nanofibers for bone regeneration

Kyohei Yamaguchi
, Mayakrishnan Prabakaran
, Ma Ke
, Xu Gang
, Ill Min Chung
, In Chul Um
, Mayakrishnan Gopiraman
, Ick Soo Kim

Department of Biofibers and Biomaterials Science

Research output: Contribution to journal › Article › peer-review

48 Scopus citations

Abstract

A successful method for fabrication of electrospun hydroxyapatite (HAp) coated cellulose nanofiber scaffold (HAp/CMC) for tissue engineering is reported. The cellulose acetate nanofibers (CANFs) were deacetylated to produce cellulose nanofibers (CNFs) which were subsequently converted to sodium carboxy methyl cellulose (Na-CMC). The Na-CMC nanofibers mat was then coated with HAp for bone regeneration applications. The FTIR results confirmed conversion of CANFs to CNFs and CNFs to Na-CMC. HAp nanocrystal growth was observed in SEM images, with crystal becoming minute and numerous upon increasing HCO3- in the simulated body fluid (SBF) solution. The proliferation of osteoblastic MC3T3-E1cells on HAp-coated CMC nanofiber mat was observed to increase with seeding time. The results confirm suitability of the HAp/CMC nanofiber mat for bone regeneration.

Original language	English
Pages (from-to)	56-61
Number of pages	6
Journal	Materials Letters
Volume	168
DOIs	https://doi.org/10.1016/j.matlet.2016.01.010
State	Published - 1 Apr 2016

Keywords

Bone regeneration
Cellulose nanofibers
Electrospinning
Hydroxyapatite
Nanocomposites

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10.1016/j.matlet.2016.01.010

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title = "Highly dispersed nanoscale hydroxyapatite on cellulose nanofibers for bone regeneration",

abstract = "A successful method for fabrication of electrospun hydroxyapatite (HAp) coated cellulose nanofiber scaffold (HAp/CMC) for tissue engineering is reported. The cellulose acetate nanofibers (CANFs) were deacetylated to produce cellulose nanofibers (CNFs) which were subsequently converted to sodium carboxy methyl cellulose (Na-CMC). The Na-CMC nanofibers mat was then coated with HAp for bone regeneration applications. The FTIR results confirmed conversion of CANFs to CNFs and CNFs to Na-CMC. HAp nanocrystal growth was observed in SEM images, with crystal becoming minute and numerous upon increasing HCO3- in the simulated body fluid (SBF) solution. The proliferation of osteoblastic MC3T3-E1cells on HAp-coated CMC nanofiber mat was observed to increase with seeding time. The results confirm suitability of the HAp/CMC nanofiber mat for bone regeneration.",

keywords = "Bone regeneration, Cellulose nanofibers, Electrospinning, Hydroxyapatite, Nanocomposites",

author = "Kyohei Yamaguchi and Mayakrishnan Prabakaran and Ma Ke and Xu Gang and Chung, \{Ill Min\} and Um, \{In Chul\} and Mayakrishnan Gopiraman and Kim, \{Ick Soo\}",

year = "2016",

month = apr,

day = "1",

doi = "10.1016/j.matlet.2016.01.010",

language = "English",

volume = "168",

pages = "56--61",

journal = "Materials Letters",

issn = "0167-577X",

publisher = "Elsevier B.V.",

}

TY - JOUR

T1 - Highly dispersed nanoscale hydroxyapatite on cellulose nanofibers for bone regeneration

AU - Yamaguchi, Kyohei

AU - Prabakaran, Mayakrishnan

AU - Ke, Ma

AU - Gang, Xu

AU - Chung, Ill Min

AU - Um, In Chul

AU - Gopiraman, Mayakrishnan

AU - Kim, Ick Soo

PY - 2016/4/1

Y1 - 2016/4/1

N2 - A successful method for fabrication of electrospun hydroxyapatite (HAp) coated cellulose nanofiber scaffold (HAp/CMC) for tissue engineering is reported. The cellulose acetate nanofibers (CANFs) were deacetylated to produce cellulose nanofibers (CNFs) which were subsequently converted to sodium carboxy methyl cellulose (Na-CMC). The Na-CMC nanofibers mat was then coated with HAp for bone regeneration applications. The FTIR results confirmed conversion of CANFs to CNFs and CNFs to Na-CMC. HAp nanocrystal growth was observed in SEM images, with crystal becoming minute and numerous upon increasing HCO3- in the simulated body fluid (SBF) solution. The proliferation of osteoblastic MC3T3-E1cells on HAp-coated CMC nanofiber mat was observed to increase with seeding time. The results confirm suitability of the HAp/CMC nanofiber mat for bone regeneration.

AB - A successful method for fabrication of electrospun hydroxyapatite (HAp) coated cellulose nanofiber scaffold (HAp/CMC) for tissue engineering is reported. The cellulose acetate nanofibers (CANFs) were deacetylated to produce cellulose nanofibers (CNFs) which were subsequently converted to sodium carboxy methyl cellulose (Na-CMC). The Na-CMC nanofibers mat was then coated with HAp for bone regeneration applications. The FTIR results confirmed conversion of CANFs to CNFs and CNFs to Na-CMC. HAp nanocrystal growth was observed in SEM images, with crystal becoming minute and numerous upon increasing HCO3- in the simulated body fluid (SBF) solution. The proliferation of osteoblastic MC3T3-E1cells on HAp-coated CMC nanofiber mat was observed to increase with seeding time. The results confirm suitability of the HAp/CMC nanofiber mat for bone regeneration.

KW - Bone regeneration

KW - Cellulose nanofibers

KW - Electrospinning

KW - Hydroxyapatite

KW - Nanocomposites

UR - https://www.scopus.com/pages/publications/84954310995

U2 - 10.1016/j.matlet.2016.01.010

DO - 10.1016/j.matlet.2016.01.010

M3 - Article

AN - SCOPUS:84954310995

SN - 0167-577X

VL - 168

SP - 56

EP - 61

JO - Materials Letters

JF - Materials Letters

ER -

Highly dispersed nanoscale hydroxyapatite on cellulose nanofibers for bone regeneration

Abstract

Keywords

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