Highly efficient synthesis and imaging studies of an arylpiperazine derivative as a 5-HT1A receptor imaging agent

Sang Hyun Park; Hui Jeong Gwon; Seung Ho Jang; Hyosun Lee

doi:10.1246/cl.2006.1304

Highly efficient synthesis and imaging studies of an arylpiperazine derivative as a 5-HT_1A receptor imaging agent

Sang Hyun Park, Hui Jeong Gwon, Seung Ho Jang, Hyosun Lee

Korea Atomic Energy Research Institute

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

A novel and straightforward microwave synthesis of a new arylpiperazine derivative 3 which has an N₂S₂ moiety has been developed and radiolabeled with an optimum radionuclide of technetium in the presence of a borohydride exchange resin (BER) as a reducing agent. According to the present study this new radiolabeled compound 4 could have the potential for a diagnostic application as an imaging agent of a serotonin neuroreceptor.

Original language	English
Pages (from-to)	1304-1305
Number of pages	2
Journal	Chemistry Letters
Volume	35
Issue number	11
DOIs	https://doi.org/10.1246/cl.2006.1304
State	Published - 5 Nov 2006

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10.1246/cl.2006.1304

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abstract = "A novel and straightforward microwave synthesis of a new arylpiperazine derivative 3 which has an N2S2 moiety has been developed and radiolabeled with an optimum radionuclide of technetium in the presence of a borohydride exchange resin (BER) as a reducing agent. According to the present study this new radiolabeled compound 4 could have the potential for a diagnostic application as an imaging agent of a serotonin neuroreceptor.",

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AU - Jang, Seung Ho

AU - Lee, Hyosun

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AB - A novel and straightforward microwave synthesis of a new arylpiperazine derivative 3 which has an N2S2 moiety has been developed and radiolabeled with an optimum radionuclide of technetium in the presence of a borohydride exchange resin (BER) as a reducing agent. According to the present study this new radiolabeled compound 4 could have the potential for a diagnostic application as an imaging agent of a serotonin neuroreceptor.

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Highly efficient synthesis and imaging studies of an arylpiperazine derivative as a 5-HT_1A receptor imaging agent

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