Hispidulin inhibits adipogenesis in 3T3-L1 adipocytes through PPARγ pathway

Seul Gi Lee, Jin Soo Kim, Kyoungjin Min, Taeg Kyu Kwon, Ju Ock Nam

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

Hispidulin, a natural flavone, has been reported to have diverse pharmacological effects, including antifungal, antioxidant, and antithrombotic properties. However, an anti-adipogenic effect has not yet been reported, which is the focus of the current study. Hispidulin suppressed the differentiation of adipocytes and cellular lipid accumulation without cytotoxicity. Treatment with hispidulin at concentrations of 10, 20, and 40 μM reduced intracellular lipids by 88.1%, 81.9%, and 75.8%, respectively. In addition, hispidulin reduced mRNA and protein expression of peroxisome proliferator-activated receptor gamma (PPARγ) and adiponectin. To our knowledge, these results are the first evidence of the anti-adipogenic effects of hispidulin in 3T3-L1 adipocytes, indicating that hispidulin has potential as a novel anti-obesity therapeutic.

Original languageEnglish
Pages (from-to)89-93
Number of pages5
JournalChemico-Biological Interactions
Volume293
DOIs
StatePublished - 25 Sep 2018

Keywords

  • 3T3-L1 adipocytes
  • Anti-adipogenic
  • Hispidulin
  • PPARγ
  • Sage

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