Histone modification in Saccharomyces cerevisiae: A review of the current status

Research output: Contribution to journalShort surveypeer-review

9 Scopus citations

Abstract

The budding yeast Saccharomyces cerevisiae is a well-characterized and popular model system for investigating histone modifications and the inheritance of chromatin states. The data obtained from this model organism have provided essential and critical information for understanding the complexity of epigenetic interactions and regulation in eukaryotes. Recent advances in biotechnology have facilitated the detection and quantitation of protein post-translational modification (PTM), including acetylation, methylation, phosphorylation, ubiquitylation, sumoylation, and acylation, and led to the identification of several novel modification sites in histones. Determining the cellular function of these new histone markers is essential for understanding epigenetic mechanisms and their impact on various biological processes. In this review, we describe recent advances and current views on histone modifications and their effects on chromatin dynamics in S. cerevisiae.

Original languageEnglish
Pages (from-to)1843-1850
Number of pages8
JournalComputational and Structural Biotechnology Journal
Volume21
DOIs
StatePublished - Jan 2023

Keywords

  • Histone acetylation
  • Histone acylation
  • Histone methylation
  • Histone phosphorylation
  • Histone sumoylation
  • Histone ubiquitylation

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