Hospital outbreak of Burkholderia stabilis bacteraemia related to contaminated chlorhexidine in haematological malignancy patients with indwelling catheters

S. T. Heo; S. J. Kim; Y. G. Jeong; I. G. Bae; J. S. Jin; J. C. Lee

doi:10.1016/j.jhin.2008.07.019

Hospital outbreak of Burkholderia stabilis bacteraemia related to contaminated chlorhexidine in haematological malignancy patients with indwelling catheters

S. T. Heo, S. J. Kim, Y. G. Jeong, I. G. Bae, J. S. Jin, J. C. Lee

Department of Medicine

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

Burkholderia cepacia complex (BCC) is an opportunistic pathogen that occasionally causes hospital outbreaks. This paper describes an outbreak of BCC bacteraemia in haematological malignancy patients related to a contaminated chlorhexidine gluconate solution. Eight BCC isolates were obtained from patients hospitalised in the same ward of a cancer centre in a Korean hospital. A further three BCC isolates were obtained from 0.5% chlorhexidine gluconate used in the same ward. The isolates were identified as B. stabilis and exhibited identical pulsed-field gel electrophoresis profiles. All patients with B. stabilis bacteraemia had indwelling intravenous catheters, which were treated with chlorhexidine to disinfect the catheters. Following identification of the source of contamination, strict controls regarding surveillance cultures for disinfectants have been enforced. No further B. stabilis infections have been found in the hospital.

Original language	English
Pages (from-to)	241-245
Number of pages	5
Journal	Journal of Hospital Infection
Volume	70
Issue number	3
DOIs	https://doi.org/10.1016/j.jhin.2008.07.019
State	Published - Nov 2008

Keywords

Burkholderia stabilis
Catheter-associated infection
Chlorhexidine
Hospital outbreak

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jhin.2008.07.019

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@article{46cdd96ef290460e953e5c4026486296,

title = "Hospital outbreak of Burkholderia stabilis bacteraemia related to contaminated chlorhexidine in haematological malignancy patients with indwelling catheters",

abstract = "Burkholderia cepacia complex (BCC) is an opportunistic pathogen that occasionally causes hospital outbreaks. This paper describes an outbreak of BCC bacteraemia in haematological malignancy patients related to a contaminated chlorhexidine gluconate solution. Eight BCC isolates were obtained from patients hospitalised in the same ward of a cancer centre in a Korean hospital. A further three BCC isolates were obtained from 0.5% chlorhexidine gluconate used in the same ward. The isolates were identified as B. stabilis and exhibited identical pulsed-field gel electrophoresis profiles. All patients with B. stabilis bacteraemia had indwelling intravenous catheters, which were treated with chlorhexidine to disinfect the catheters. Following identification of the source of contamination, strict controls regarding surveillance cultures for disinfectants have been enforced. No further B. stabilis infections have been found in the hospital.",

keywords = "Burkholderia stabilis, Catheter-associated infection, Chlorhexidine, Hospital outbreak",

author = "Heo, {S. T.} and Kim, {S. J.} and Jeong, {Y. G.} and Bae, {I. G.} and Jin, {J. S.} and Lee, {J. C.}",

year = "2008",

month = nov,

doi = "10.1016/j.jhin.2008.07.019",

language = "English",

volume = "70",

pages = "241--245",

journal = "Journal of Hospital Infection",

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T1 - Hospital outbreak of Burkholderia stabilis bacteraemia related to contaminated chlorhexidine in haematological malignancy patients with indwelling catheters

AU - Heo, S. T.

AU - Kim, S. J.

AU - Jeong, Y. G.

AU - Bae, I. G.

AU - Jin, J. S.

AU - Lee, J. C.

PY - 2008/11

Y1 - 2008/11

N2 - Burkholderia cepacia complex (BCC) is an opportunistic pathogen that occasionally causes hospital outbreaks. This paper describes an outbreak of BCC bacteraemia in haematological malignancy patients related to a contaminated chlorhexidine gluconate solution. Eight BCC isolates were obtained from patients hospitalised in the same ward of a cancer centre in a Korean hospital. A further three BCC isolates were obtained from 0.5% chlorhexidine gluconate used in the same ward. The isolates were identified as B. stabilis and exhibited identical pulsed-field gel electrophoresis profiles. All patients with B. stabilis bacteraemia had indwelling intravenous catheters, which were treated with chlorhexidine to disinfect the catheters. Following identification of the source of contamination, strict controls regarding surveillance cultures for disinfectants have been enforced. No further B. stabilis infections have been found in the hospital.

AB - Burkholderia cepacia complex (BCC) is an opportunistic pathogen that occasionally causes hospital outbreaks. This paper describes an outbreak of BCC bacteraemia in haematological malignancy patients related to a contaminated chlorhexidine gluconate solution. Eight BCC isolates were obtained from patients hospitalised in the same ward of a cancer centre in a Korean hospital. A further three BCC isolates were obtained from 0.5% chlorhexidine gluconate used in the same ward. The isolates were identified as B. stabilis and exhibited identical pulsed-field gel electrophoresis profiles. All patients with B. stabilis bacteraemia had indwelling intravenous catheters, which were treated with chlorhexidine to disinfect the catheters. Following identification of the source of contamination, strict controls regarding surveillance cultures for disinfectants have been enforced. No further B. stabilis infections have been found in the hospital.

KW - Burkholderia stabilis

KW - Catheter-associated infection

KW - Chlorhexidine

KW - Hospital outbreak

UR - http://www.scopus.com/inward/record.url?scp=52949148160&partnerID=8YFLogxK

U2 - 10.1016/j.jhin.2008.07.019

DO - 10.1016/j.jhin.2008.07.019

M3 - Article

C2 - 18799235

AN - SCOPUS:52949148160

SN - 0195-6701

VL - 70

SP - 241

EP - 245

JO - Journal of Hospital Infection

JF - Journal of Hospital Infection

IS - 3

ER -

Hospital outbreak of Burkholderia stabilis bacteraemia related to contaminated chlorhexidine in haematological malignancy patients with indwelling catheters

Abstract

Keywords

UN SDGs

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