Abstract
When the skin is seriously damaged through disease or trauma, artificial skin using synthetic or natural polymer is essential due to limitation of self-repair and donor-site morbidity. Generally, microfiber has demerit of cell maintenance limits after cell seeding and nanofiber has demerit of structural weakness. In this study, we prepared hybrid scaffolds composed of the nanofibers of chitosan-poly(lactic-co-glycolic acid) (PLGA)-poly ethylene oxide and microfibers of PLGA for artificial skin. The morphology and hydrophilicity of the scaffolds were characterized by scanning electron microscope (SEM) and contact angle machine. Dermal sheath cells, one of hair follicle stem cells were applied on the scaffolds and analyzed. Hybrid scaffolds possessed high hydrophilicity and exhibited good cell adhesion and viability at appropriate nano/microfiber ratio. Thus, this hybrid scaffold shows a potential as a material for artificial skin.
| Original language | English |
|---|---|
| Pages (from-to) | 108-115 |
| Number of pages | 8 |
| Journal | Tissue Engineering and Regenerative Medicine |
| Volume | 8 |
| Issue number | SUPPL.2 |
| State | Published - Jul 2011 |
Keywords
- Artificial skin
- Dermal sheath cells
- Hybrid scaffold
- Micro fiber
- Nano fiber