Hydroxypropyl methylcellulose-graft-poly(ethyl acrylate-co-methyl methacrylate) particles by resin-fortified emulsion polymerization

Hyon Ho Baek; Jung Min Lee; Ji Eun Cho; Jin Hun Cho; Jung Hyun Kim; In Woo Cheong

doi:10.1007/s13233-009-0097-9

Hydroxypropyl methylcellulose-graft-poly(ethyl acrylate-co-methyl methacrylate) particles by resin-fortified emulsion polymerization

Hyon Ho Baek, Jung Min Lee, Ji Eun Cho, Jin Hun Cho, Jung Hyun Kim, In Woo Cheong

Yonsei University

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

This article describes the preparation and characterization of hydroxypropyl methylcellulose-graft-poly(ethylacrylate-co-methyl methacrylate) particles [HPMC-g-poly(EA-co-MMA) NPs]. The particles were prepared by resin-fortified emulsion polymerization using ceric ammonium nitrate (CAN). In this study, a series of HPMC-g-poly(EA-co-MMA) NPs were synthesized by varying the CAN: HPMC and HPMC: (EA/MMA) ratios to determine the effects of these variables on the physical properties of HPMC-g-poly(EA-co-MMA) as well as the dissolution behavior of an aspirin tablet, as a model drug. The drug dissolution profiles of the coated tablets were affected significantly by the HPMC: (EA/MMA) molar ratio.

Original language	English
Pages (from-to)	53-58
Number of pages	6
Journal	Macromolecular Research
Volume	18
Issue number	1
DOIs	https://doi.org/10.1007/s13233-009-0097-9
State	Published - Jan 2010

Keywords

drug release
hydroxypropyl methylcellulose
redox initiation
resin-fortified emulsion polymerization

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title = "Hydroxypropyl methylcellulose-graft-poly(ethyl acrylate-co-methyl methacrylate) particles by resin-fortified emulsion polymerization",

abstract = "This article describes the preparation and characterization of hydroxypropyl methylcellulose-graft-poly(ethylacrylate-co-methyl methacrylate) particles [HPMC-g-poly(EA-co-MMA) NPs]. The particles were prepared by resin-fortified emulsion polymerization using ceric ammonium nitrate (CAN). In this study, a series of HPMC-g-poly(EA-co-MMA) NPs were synthesized by varying the CAN: HPMC and HPMC: (EA/MMA) ratios to determine the effects of these variables on the physical properties of HPMC-g-poly(EA-co-MMA) as well as the dissolution behavior of an aspirin tablet, as a model drug. The drug dissolution profiles of the coated tablets were affected significantly by the HPMC: (EA/MMA) molar ratio.",

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author = "Baek, {Hyon Ho} and Lee, {Jung Min} and Cho, {Ji Eun} and Cho, {Jin Hun} and Kim, {Jung Hyun} and Cheong, {In Woo}",

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AU - Baek, Hyon Ho

AU - Lee, Jung Min

AU - Cho, Ji Eun

AU - Cho, Jin Hun

AU - Kim, Jung Hyun

AU - Cheong, In Woo

PY - 2010/1

Y1 - 2010/1

N2 - This article describes the preparation and characterization of hydroxypropyl methylcellulose-graft-poly(ethylacrylate-co-methyl methacrylate) particles [HPMC-g-poly(EA-co-MMA) NPs]. The particles were prepared by resin-fortified emulsion polymerization using ceric ammonium nitrate (CAN). In this study, a series of HPMC-g-poly(EA-co-MMA) NPs were synthesized by varying the CAN: HPMC and HPMC: (EA/MMA) ratios to determine the effects of these variables on the physical properties of HPMC-g-poly(EA-co-MMA) as well as the dissolution behavior of an aspirin tablet, as a model drug. The drug dissolution profiles of the coated tablets were affected significantly by the HPMC: (EA/MMA) molar ratio.

AB - This article describes the preparation and characterization of hydroxypropyl methylcellulose-graft-poly(ethylacrylate-co-methyl methacrylate) particles [HPMC-g-poly(EA-co-MMA) NPs]. The particles were prepared by resin-fortified emulsion polymerization using ceric ammonium nitrate (CAN). In this study, a series of HPMC-g-poly(EA-co-MMA) NPs were synthesized by varying the CAN: HPMC and HPMC: (EA/MMA) ratios to determine the effects of these variables on the physical properties of HPMC-g-poly(EA-co-MMA) as well as the dissolution behavior of an aspirin tablet, as a model drug. The drug dissolution profiles of the coated tablets were affected significantly by the HPMC: (EA/MMA) molar ratio.

KW - drug release

KW - hydroxypropyl methylcellulose

KW - redox initiation

KW - resin-fortified emulsion polymerization

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Hydroxypropyl methylcellulose-graft-poly(ethyl acrylate-co-methyl methacrylate) particles by resin-fortified emulsion polymerization

Abstract

Keywords

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