Hyperoside Inhibits High-Glucose-Induced Vascular Inflammation In Vitro and In Vivo

Sae Kwang Ku, Soyoung Kwak, O. Jun Kwon, Jong Sup Bae

Research output: Contribution to journalArticlepeer-review

71 Scopus citations

Abstract

Hyperoside, an active compound from the genera of Hypericum and Crataegus, was reported to have antioxidant, antihyperglycemic, anticancer, anti-inflammatory, and anticoagulant activities. Vascular inflammatory process has been suggested to play a key role in initiation and progression of atherosclerosis, a major complication of diabetes mellitus. Thus, in this study, we attempted to determine whether hyperoside can suppress vascular inflammatory processes induced by high glucose (HG) in human umbilical vein endothelial cells (HUVECs) and mice. Data showed that HG induced markedly increased vascular permeability, monocyte adhesion, expressions of cell adhesion molecules (CAMs), formation of reactive oxygen species (ROS), and activation of nuclear factor (NF)-κB. Remarkably, all of the above-mentioned vascular inflammatory effects of HG were attenuated by pretreatment with hyperoside. Vascular inflammatory responses induced by HG are critical events underlying development of various diabetic complications; therefore, our results suggest that hyperoside may have significant therapeutic benefits against diabetic complications and atherosclerosis.

Original languageEnglish
Pages (from-to)1389-1400
Number of pages12
JournalInflammation
Volume37
Issue number5
DOIs
StatePublished - 24 Sep 2014

Keywords

  • atherosclerosis
  • diabetes mellitus
  • high glucose
  • hyperoside
  • inflammation

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