Identification and characterization of rabbit hemorrhagic disease virus genetic variants isolated in Korea

Jae Ku Oem; Kwang Nyeong Lee; In Soon Roh; Kyoung Ki Lee; Seong Hee Kim; Ryoung Hye Kim; Choi Kyu Park; Yi Seok Joo

doi:10.1292/jvms.001519

Identification and characterization of rabbit hemorrhagic disease virus genetic variants isolated in Korea

Jae Ku Oem, Kwang Nyeong Lee, In Soon Roh, Kyoung Ki Lee, Seong Hee Kim, Ryoung Hye Kim, Choi Kyu Park, Yi Seok Joo

Department of Veterinary Medicine

Ministry of Agriculture, Food and Rural Affairs

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

Nine isolates of rabbit hemorrhagic disease virus (RHDV) were used for the genetic characterization of RHDV strains collected from rabbits in Korea between 2006 and 2008. A phylogenetic analysis of the complete VP60 region was performed and the sequences were divided mainly into two groups. The one group consisted of original RHDV and the other contained antigenic variant strain known as RHDVa strains. Most of the Korean isolates clustered with Chinese RHDV strains and belonged to the RHDVa subtype. A comparison of the amino acid sequences among RHDVa strains and original RHDV strains revealed significant substitutions of two amino acids in the A region, two in the B region, two in the F region, and nine amino acids in the E region. Taken together, the recent RHDVa strains have gradually replaced the original RHDV and are the predominant strains in Korea.

Original language	English
Pages (from-to)	1519-1523
Number of pages	5
Journal	Journal of Veterinary Medical Science
Volume	71
Issue number	11
DOIs	https://doi.org/10.1292/jvms.001519
State	Published - Nov 2009

Keywords

Phylogenetic analysis
RHDV

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10.1292/jvms.001519

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title = "Identification and characterization of rabbit hemorrhagic disease virus genetic variants isolated in Korea",

abstract = "Nine isolates of rabbit hemorrhagic disease virus (RHDV) were used for the genetic characterization of RHDV strains collected from rabbits in Korea between 2006 and 2008. A phylogenetic analysis of the complete VP60 region was performed and the sequences were divided mainly into two groups. The one group consisted of original RHDV and the other contained antigenic variant strain known as RHDVa strains. Most of the Korean isolates clustered with Chinese RHDV strains and belonged to the RHDVa subtype. A comparison of the amino acid sequences among RHDVa strains and original RHDV strains revealed significant substitutions of two amino acids in the A region, two in the B region, two in the F region, and nine amino acids in the E region. Taken together, the recent RHDVa strains have gradually replaced the original RHDV and are the predominant strains in Korea.",

keywords = "Phylogenetic analysis, RHDV",

author = "Oem, {Jae Ku} and Lee, {Kwang Nyeong} and Roh, {In Soon} and Lee, {Kyoung Ki} and Kim, {Seong Hee} and Kim, {Ryoung Hye} and Park, {Choi Kyu} and Joo, {Yi Seok}",

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T1 - Identification and characterization of rabbit hemorrhagic disease virus genetic variants isolated in Korea

AU - Oem, Jae Ku

AU - Lee, Kwang Nyeong

AU - Roh, In Soon

AU - Lee, Kyoung Ki

AU - Kim, Seong Hee

AU - Kim, Ryoung Hye

AU - Park, Choi Kyu

AU - Joo, Yi Seok

PY - 2009/11

Y1 - 2009/11

N2 - Nine isolates of rabbit hemorrhagic disease virus (RHDV) were used for the genetic characterization of RHDV strains collected from rabbits in Korea between 2006 and 2008. A phylogenetic analysis of the complete VP60 region was performed and the sequences were divided mainly into two groups. The one group consisted of original RHDV and the other contained antigenic variant strain known as RHDVa strains. Most of the Korean isolates clustered with Chinese RHDV strains and belonged to the RHDVa subtype. A comparison of the amino acid sequences among RHDVa strains and original RHDV strains revealed significant substitutions of two amino acids in the A region, two in the B region, two in the F region, and nine amino acids in the E region. Taken together, the recent RHDVa strains have gradually replaced the original RHDV and are the predominant strains in Korea.

AB - Nine isolates of rabbit hemorrhagic disease virus (RHDV) were used for the genetic characterization of RHDV strains collected from rabbits in Korea between 2006 and 2008. A phylogenetic analysis of the complete VP60 region was performed and the sequences were divided mainly into two groups. The one group consisted of original RHDV and the other contained antigenic variant strain known as RHDVa strains. Most of the Korean isolates clustered with Chinese RHDV strains and belonged to the RHDVa subtype. A comparison of the amino acid sequences among RHDVa strains and original RHDV strains revealed significant substitutions of two amino acids in the A region, two in the B region, two in the F region, and nine amino acids in the E region. Taken together, the recent RHDVa strains have gradually replaced the original RHDV and are the predominant strains in Korea.

KW - Phylogenetic analysis

KW - RHDV

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Identification and characterization of rabbit hemorrhagic disease virus genetic variants isolated in Korea

Abstract

Keywords

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