Identification of genetic polymorphisms in FABP3 and FABP4 and putative association with back fat thickness in Korean native cattle

Seoae Cho; Sung Park Tae; Du Hak Yoon; Sub Cheong Hyun; Sohg Namgoong; Lae Park Byung; Won Lee Hye; Soo Han Chang; Mi Kim Eun; Il Cheong Cheong; Heebal Kim; Doo Shin Hyoung

doi:10.5483/bmbrep.2008.41.1.029

Identification of genetic polymorphisms in FABP3 and FABP4 and putative association with back fat thickness in Korean native cattle

Seoae Cho, Sung Park Tae, Du Hak Yoon, Sub Cheong Hyun, Sohg Namgoong, Lae Park Byung, Won Lee Hye, Soo Han Chang, Mi Kim Eun, Il Cheong Cheong, Heebal Kim, Doo Shin Hyoung

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Abstract

The aim of this study was to determine whether single nucleotide polymorphisms (SNP) in the beef cattle adipocyte fatty-acid binding protein 3 and 4 (FABP3 and FABP4) genes are associated with carcass weight (CW) and back fat thickness (BF) of beef cattle. By direct DNA sequencing in 24 unrelated Korean native cattle, we identified 20 SNPs in FABP3 and FABP4. Among them, 10 polymorphic sites were selected for genotyping in our beef cattle. We performed SNP, haplotype and linkage disequilibrium studies on 419 Korean native cattle with the 10 SNPs in the FABP genes. Statistical analysis revealed that 220A>G (I74V) and 348+303T>C polymorphisms in FABP4 showed putative associations with BF traits (P =0.02 and 0.01, respectively). Our findings suggest that the polymorphisms in FABP4 may play a role in determining one of the important genetic factors that influence BF in beef cattle.

Original language	English
Pages (from-to)	29-34
Number of pages	6
Journal	Journal of Biochemistry and Molecular Biology
Volume	41
Issue number	1
DOIs	https://doi.org/10.5483/bmbrep.2008.41.1.029
State	Published - Jan 2008

Keywords

Back fat thickness
FABP3
FABP4
Korean native cattle
Single nucleotide polymorphism

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10.5483/bmbrep.2008.41.1.029

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Cho, S., Tae, S. P., Yoon, D. H., Hyun, S. C., Namgoong, S., Byung, L. P., Hye, W. L., Chang, S. H., Eun, M. K., Cheong, I. C., Kim, H., & Hyoung, D. S. (2008). Identification of genetic polymorphisms in FABP3 and FABP4 and putative association with back fat thickness in Korean native cattle. Journal of Biochemistry and Molecular Biology, 41(1), 29-34. https://doi.org/10.5483/bmbrep.2008.41.1.029

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title = "Identification of genetic polymorphisms in FABP3 and FABP4 and putative association with back fat thickness in Korean native cattle",

abstract = "The aim of this study was to determine whether single nucleotide polymorphisms (SNP) in the beef cattle adipocyte fatty-acid binding protein 3 and 4 (FABP3 and FABP4) genes are associated with carcass weight (CW) and back fat thickness (BF) of beef cattle. By direct DNA sequencing in 24 unrelated Korean native cattle, we identified 20 SNPs in FABP3 and FABP4. Among them, 10 polymorphic sites were selected for genotyping in our beef cattle. We performed SNP, haplotype and linkage disequilibrium studies on 419 Korean native cattle with the 10 SNPs in the FABP genes. Statistical analysis revealed that 220A>G (I74V) and 348+303T>C polymorphisms in FABP4 showed putative associations with BF traits (P =0.02 and 0.01, respectively). Our findings suggest that the polymorphisms in FABP4 may play a role in determining one of the important genetic factors that influence BF in beef cattle.",

keywords = "Back fat thickness, FABP3, FABP4, Korean native cattle, Single nucleotide polymorphism",

author = "Seoae Cho and Tae, {Sung Park} and Yoon, {Du Hak} and Hyun, {Sub Cheong} and Sohg Namgoong and Byung, {Lae Park} and Hye, {Won Lee} and Chang, {Soo Han} and Eun, {Mi Kim} and Cheong, {Il Cheong} and Heebal Kim and Hyoung, {Doo Shin}",

year = "2008",

month = jan,

doi = "10.5483/bmbrep.2008.41.1.029",

language = "English",

volume = "41",

pages = "29--34",

journal = "Journal of Biochemistry and Molecular Biology",

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publisher = "The Biochemical Society of the Republic of Korea",

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Cho, S, Tae, SP, Yoon, DH, Hyun, SC, Namgoong, S, Byung, LP, Hye, WL, Chang, SH, Eun, MK, Cheong, IC, Kim, H & Hyoung, DS 2008, 'Identification of genetic polymorphisms in FABP3 and FABP4 and putative association with back fat thickness in Korean native cattle', Journal of Biochemistry and Molecular Biology, vol. 41, no. 1, pp. 29-34. https://doi.org/10.5483/bmbrep.2008.41.1.029

TY - JOUR

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AU - Cho, Seoae

AU - Tae, Sung Park

AU - Yoon, Du Hak

AU - Hyun, Sub Cheong

AU - Namgoong, Sohg

AU - Byung, Lae Park

AU - Hye, Won Lee

AU - Chang, Soo Han

AU - Eun, Mi Kim

AU - Cheong, Il Cheong

AU - Kim, Heebal

AU - Hyoung, Doo Shin

PY - 2008/1

Y1 - 2008/1

N2 - The aim of this study was to determine whether single nucleotide polymorphisms (SNP) in the beef cattle adipocyte fatty-acid binding protein 3 and 4 (FABP3 and FABP4) genes are associated with carcass weight (CW) and back fat thickness (BF) of beef cattle. By direct DNA sequencing in 24 unrelated Korean native cattle, we identified 20 SNPs in FABP3 and FABP4. Among them, 10 polymorphic sites were selected for genotyping in our beef cattle. We performed SNP, haplotype and linkage disequilibrium studies on 419 Korean native cattle with the 10 SNPs in the FABP genes. Statistical analysis revealed that 220A>G (I74V) and 348+303T>C polymorphisms in FABP4 showed putative associations with BF traits (P =0.02 and 0.01, respectively). Our findings suggest that the polymorphisms in FABP4 may play a role in determining one of the important genetic factors that influence BF in beef cattle.

AB - The aim of this study was to determine whether single nucleotide polymorphisms (SNP) in the beef cattle adipocyte fatty-acid binding protein 3 and 4 (FABP3 and FABP4) genes are associated with carcass weight (CW) and back fat thickness (BF) of beef cattle. By direct DNA sequencing in 24 unrelated Korean native cattle, we identified 20 SNPs in FABP3 and FABP4. Among them, 10 polymorphic sites were selected for genotyping in our beef cattle. We performed SNP, haplotype and linkage disequilibrium studies on 419 Korean native cattle with the 10 SNPs in the FABP genes. Statistical analysis revealed that 220A>G (I74V) and 348+303T>C polymorphisms in FABP4 showed putative associations with BF traits (P =0.02 and 0.01, respectively). Our findings suggest that the polymorphisms in FABP4 may play a role in determining one of the important genetic factors that influence BF in beef cattle.

KW - Back fat thickness

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KW - FABP4

KW - Korean native cattle

KW - Single nucleotide polymorphism

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SN - 1225-8687

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Identification of genetic polymorphisms in FABP3 and FABP4 and putative association with back fat thickness in Korean native cattle

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Keywords

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