Identification of potential inflammatory inhibitors from Aster tataricus

Xiang Dong Su, Hyun Jae Jang, Hong Xu Li, Young Ho Kim, Seo Young Yang

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

Aster tataricus L.f. is a traditional Eastern Asian herbal medicine used for the relief of cough-related illnesses. In this study, 32 known compounds and two novel monoterpene glycosides were isolated from the roots of A. tataricus. With the aid of reported data, elucidation of the root-extract components was carried out using a multitude of spectroscopic techniques. All isolates were investigated for their ability to inhibit nitric oxide (NO) secretion in lipopolysaccharide-activated RAW264.7 cells. Compound 7 remarkably suppressed NO production with an IC50 value of 8.5 µM. In addition, compound 7 exhibited significant inhibitory activity against the production of inflammatory cytokines (prostaglandin E2, interleukin-6, and interleukin-1 beta) and the expression of inflammatory enzymes (inducible nitric oxide synthase and cyclooxygenase-2) via inhibition of nuclear factor-kappa B activation. Moreover, compound 7 effectively prevented the downstream activation of the mitogen-activated protein kinase signaling pathway by inhibiting phosphorylation of c-Jun N-terminal kinases, extracellular signal-regulated kinases, and p38. These results outline compound 7 as a potential inhibitor for the broad treatment of inflammatory diseases, such as atopic dermatitis, asthma, and various allergies.

Original languageEnglish
Article number103208
JournalBioorganic Chemistry
Volume92
DOIs
StatePublished - Nov 2019

Keywords

  • Aster tataricus
  • Asteraceae
  • Inflammatory
  • MAPKs
  • NF-κB

Fingerprint

Dive into the research topics of 'Identification of potential inflammatory inhibitors from Aster tataricus'. Together they form a unique fingerprint.

Cite this