Imaging nanoparticle flow using magneto-motive optical Doppler tomography

Jeehyun Kim; Junghwan Oh; Thomas E. Milner; J. Stuart Nelson

doi:10.1088/0957-4484/18/3/035504

Imaging nanoparticle flow using magneto-motive optical Doppler tomography

Jeehyun Kim, Junghwan Oh, Thomas E. Milner, J. Stuart Nelson

School of Electronics Engineering

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

We introduce a novel approach for imaging solutions of superparamagnetic iron oxide (SPIO) nanoparticles using magneto-motive optical Doppler tomography (MM-ODT). MM-ODT combines an externally applied temporally oscillating high-strength magnetic field with ODT to detect nanoparticles flowing through a microfluidic channel. A solenoid with a cone-shaped ferrite core extensively increased the magnetic field strength (B_max ≤ 1T, ) at the tip of the core and also focused the magnetic field in microfluidic channels containing nanoparticle solutions. Nanoparticle contrast was demonstrated in a microfluidic channel filled with an SPIO solution by imaging the Doppler frequency shift which was observed independently of the nanoparticle flow rate and direction. Results suggest that MM-ODT may be applied to image Doppler shift of SPIO nanoparticles in microfluidic flows with high contrast.

Original language	English
Article number	035504
Journal	Nanotechnology
Volume	18
Issue number	3
DOIs	https://doi.org/10.1088/0957-4484/18/3/035504
State	Published - 24 Jan 2007

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abstract = "We introduce a novel approach for imaging solutions of superparamagnetic iron oxide (SPIO) nanoparticles using magneto-motive optical Doppler tomography (MM-ODT). MM-ODT combines an externally applied temporally oscillating high-strength magnetic field with ODT to detect nanoparticles flowing through a microfluidic channel. A solenoid with a cone-shaped ferrite core extensively increased the magnetic field strength (Bmax ≤ 1T, ) at the tip of the core and also focused the magnetic field in microfluidic channels containing nanoparticle solutions. Nanoparticle contrast was demonstrated in a microfluidic channel filled with an SPIO solution by imaging the Doppler frequency shift which was observed independently of the nanoparticle flow rate and direction. Results suggest that MM-ODT may be applied to image Doppler shift of SPIO nanoparticles in microfluidic flows with high contrast.",

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Imaging nanoparticle flow using magneto-motive optical Doppler tomography

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