TY - JOUR
T1 - Impact of chlorogenic acid on modulation of significant genes in dermal fibroblasts and epidermal keratinocytes
AU - Lee, Kyung Ha
AU - Do, Hwan Kwon
AU - Kim, Do Yeon
AU - Kim, Wanil
N1 - Publisher Copyright:
© 2021 Elsevier Inc.
PY - 2021/12/17
Y1 - 2021/12/17
N2 - Chlorogenic acid is one of the most abundant polyphenols found in human diet. It is well-documented that chlorogenic acid has a significant impact on human cells, especially in the regulation of inflammation and metabolic processes. However, its role in regulating skin functions, especially with respect to the dermal collagen network or epidermal skin barrier, has not yet been elucidated. Here, we report that chlorogenic acid treatment can induce production of procollagen type I in human dermal fibroblast, Hs68 cell lines. Moreover, this treatment can stimulate upregulation of skin barrier genes, including the ones encoding filaggrin (FLG), involucrin (IVL), and envoplakin (EVPL), in epidermal keratinocytes. Chlorogenic acid also triggered a multifaceted response in the cytokine profile of keratinocytes. Therefore, we suggest that chlorogenic acid can be used to restore the impaired dermal matrix network as well as the epidermal skin barrier.
AB - Chlorogenic acid is one of the most abundant polyphenols found in human diet. It is well-documented that chlorogenic acid has a significant impact on human cells, especially in the regulation of inflammation and metabolic processes. However, its role in regulating skin functions, especially with respect to the dermal collagen network or epidermal skin barrier, has not yet been elucidated. Here, we report that chlorogenic acid treatment can induce production of procollagen type I in human dermal fibroblast, Hs68 cell lines. Moreover, this treatment can stimulate upregulation of skin barrier genes, including the ones encoding filaggrin (FLG), involucrin (IVL), and envoplakin (EVPL), in epidermal keratinocytes. Chlorogenic acid also triggered a multifaceted response in the cytokine profile of keratinocytes. Therefore, we suggest that chlorogenic acid can be used to restore the impaired dermal matrix network as well as the epidermal skin barrier.
KW - Chlorogenic acid
KW - Collagen
KW - Dermal protein matrix
KW - Epidermal skin barrier
KW - Skin barrier genes
UR - http://www.scopus.com/inward/record.url?scp=85117935626&partnerID=8YFLogxK
U2 - 10.1016/j.bbrc.2021.10.057
DO - 10.1016/j.bbrc.2021.10.057
M3 - Article
C2 - 34715497
AN - SCOPUS:85117935626
SN - 0006-291X
VL - 583
SP - 22
EP - 28
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
ER -