Improved magnetic relaxivity via hierarchical surface structure of dysprosium-engineered superparamagnetic iron oxide nanoparticles in ultra-high magnetic field

Jeong Chan Park; Jun Kue Park; Gyeong Tae Lee; Do Hyeon Kim; Hyunsil Cha; Tae Yoon Park; Maengjun Kim; Yongmin Chang; Hyung Joon Cha; Jeong Hyun Seo

doi:10.1016/j.jiec.2019.05.004

Improved magnetic relaxivity via hierarchical surface structure of dysprosium-engineered superparamagnetic iron oxide nanoparticles in ultra-high magnetic field

Jeong Chan Park
, Jun Kue Park
, Gyeong Tae Lee
, Do Hyeon Kim
, Hyunsil Cha
, Tae Yoon Park
, Maengjun Kim
, Yongmin Chang
, Hyung Joon Cha
, Jeong Hyun Seo

Department of Medicine

Pohang University of Science and Technology
Korea Atomic Energy Research Institute
Yeungnam University
Kyungpook National University

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

To date, it is unknown whether the combination of Dy ions and superparamagnetic iron oxide (SPIO; Fe₃O₄) NPs can offer improved performance in UHF-MRI. In this work, we provide a paradigm of hierarchical surface-structured (His) Dy_xFe_3- _xO₄ NPs as T₂ MRI nanoprobes at UHF (9.4 T). We found that His-Dy_xFe_3- _xO₄ NPs (x = 0.2) possess a higher transverse relaxivity than unmodified His-SPIO NPs and a significantly enhanced r₂/r₁ ratio (up to ˜10.4 times higher) than those of reported Dy-based T₂ MRI probes at 9.4 T. Furthermore, we demonstrate the effects of surface design of Dy_xFe_3- _xO₄ NPs on their magnetic relaxivity and in vivo performance at UHF. The markedly enhanced r₂/r₁ of His-Dy_xFe_3- _xO₄ NPs (x = 0.2) at 9.4 T is mainly attributed to decreased r₁ relaxivity owing to the surface design and the possible disturbance of the Dy-Fe superexchange interaction. This work could provide an insightful strategy for the design of lanthanide-doped magnetic nanosystems as potential T₂ MRI nanoprobes in UHF.

Original language	English
Pages (from-to)	408-415
Number of pages	8
Journal	Journal of Industrial and Engineering Chemistry
Volume	77
DOIs	https://doi.org/10.1016/j.jiec.2019.05.004
State	Published - 25 Sep 2019

Keywords

Dysprosium
Hierarchical surface structure
Magnetic relaxivity
Superparamagnetic iron oxide nanoparticles
Ultra-high-field magnetic resonance imaging

Access to Document

10.1016/j.jiec.2019.05.004

Cite this

Park, J. C., Park, J. K., Lee, G. T., Kim, D. H., Cha, H., Park, T. Y., Kim, M., Chang, Y., Cha, H. J., & Seo, J. H. (2019). Improved magnetic relaxivity via hierarchical surface structure of dysprosium-engineered superparamagnetic iron oxide nanoparticles in ultra-high magnetic field. Journal of Industrial and Engineering Chemistry, 77, 408-415. https://doi.org/10.1016/j.jiec.2019.05.004

@article{52a0e58b1e8547b6b95b26ef8a2516c8,

title = "Improved magnetic relaxivity via hierarchical surface structure of dysprosium-engineered superparamagnetic iron oxide nanoparticles in ultra-high magnetic field",

abstract = "To date, it is unknown whether the combination of Dy ions and superparamagnetic iron oxide (SPIO; Fe3O4) NPs can offer improved performance in UHF-MRI. In this work, we provide a paradigm of hierarchical surface-structured (His) DyxFe3- xO4 NPs as T2 MRI nanoprobes at UHF (9.4 T). We found that His-DyxFe3- xO4 NPs (x = 0.2) possess a higher transverse relaxivity than unmodified His-SPIO NPs and a significantly enhanced r2/r1 ratio (up to ˜10.4 times higher) than those of reported Dy-based T2 MRI probes at 9.4 T. Furthermore, we demonstrate the effects of surface design of DyxFe3- xO4 NPs on their magnetic relaxivity and in vivo performance at UHF. The markedly enhanced r2/r1 of His-DyxFe3- xO4 NPs (x = 0.2) at 9.4 T is mainly attributed to decreased r1 relaxivity owing to the surface design and the possible disturbance of the Dy-Fe superexchange interaction. This work could provide an insightful strategy for the design of lanthanide-doped magnetic nanosystems as potential T2 MRI nanoprobes in UHF.",

keywords = "Dysprosium, Hierarchical surface structure, Magnetic relaxivity, Superparamagnetic iron oxide nanoparticles, Ultra-high-field magnetic resonance imaging",

author = "Park, \{Jeong Chan\} and Park, \{Jun Kue\} and Lee, \{Gyeong Tae\} and Kim, \{Do Hyeon\} and Hyunsil Cha and Park, \{Tae Yoon\} and Maengjun Kim and Yongmin Chang and Cha, \{Hyung Joon\} and Seo, \{Jeong Hyun\}",

note = "Publisher Copyright: {\textcopyright} 2019 The Korean Society of Industrial and Engineering Chemistry",

year = "2019",

month = sep,

day = "25",

doi = "10.1016/j.jiec.2019.05.004",

language = "English",

volume = "77",

pages = "408--415",

journal = "Journal of Industrial and Engineering Chemistry",

issn = "1226-086X",

publisher = "Korean Society of Industrial Engineering Chemistry",

}

Park, JC, Park, JK, Lee, GT, Kim, DH, Cha, H, Park, TY, Kim, M, Chang, Y, Cha, HJ & Seo, JH 2019, 'Improved magnetic relaxivity via hierarchical surface structure of dysprosium-engineered superparamagnetic iron oxide nanoparticles in ultra-high magnetic field', Journal of Industrial and Engineering Chemistry, vol. 77, pp. 408-415. https://doi.org/10.1016/j.jiec.2019.05.004

Improved magnetic relaxivity via hierarchical surface structure of dysprosium-engineered superparamagnetic iron oxide nanoparticles in ultra-high magnetic field. / Park, Jeong Chan; Park, Jun Kue; Lee, Gyeong Tae et al.
In: Journal of Industrial and Engineering Chemistry, Vol. 77, 25.09.2019, p. 408-415.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Improved magnetic relaxivity via hierarchical surface structure of dysprosium-engineered superparamagnetic iron oxide nanoparticles in ultra-high magnetic field

AU - Park, Jeong Chan

AU - Park, Jun Kue

AU - Lee, Gyeong Tae

AU - Kim, Do Hyeon

AU - Cha, Hyunsil

AU - Park, Tae Yoon

AU - Kim, Maengjun

AU - Chang, Yongmin

AU - Cha, Hyung Joon

AU - Seo, Jeong Hyun

PY - 2019/9/25

Y1 - 2019/9/25

N2 - To date, it is unknown whether the combination of Dy ions and superparamagnetic iron oxide (SPIO; Fe3O4) NPs can offer improved performance in UHF-MRI. In this work, we provide a paradigm of hierarchical surface-structured (His) DyxFe3- xO4 NPs as T2 MRI nanoprobes at UHF (9.4 T). We found that His-DyxFe3- xO4 NPs (x = 0.2) possess a higher transverse relaxivity than unmodified His-SPIO NPs and a significantly enhanced r2/r1 ratio (up to ˜10.4 times higher) than those of reported Dy-based T2 MRI probes at 9.4 T. Furthermore, we demonstrate the effects of surface design of DyxFe3- xO4 NPs on their magnetic relaxivity and in vivo performance at UHF. The markedly enhanced r2/r1 of His-DyxFe3- xO4 NPs (x = 0.2) at 9.4 T is mainly attributed to decreased r1 relaxivity owing to the surface design and the possible disturbance of the Dy-Fe superexchange interaction. This work could provide an insightful strategy for the design of lanthanide-doped magnetic nanosystems as potential T2 MRI nanoprobes in UHF.

AB - To date, it is unknown whether the combination of Dy ions and superparamagnetic iron oxide (SPIO; Fe3O4) NPs can offer improved performance in UHF-MRI. In this work, we provide a paradigm of hierarchical surface-structured (His) DyxFe3- xO4 NPs as T2 MRI nanoprobes at UHF (9.4 T). We found that His-DyxFe3- xO4 NPs (x = 0.2) possess a higher transverse relaxivity than unmodified His-SPIO NPs and a significantly enhanced r2/r1 ratio (up to ˜10.4 times higher) than those of reported Dy-based T2 MRI probes at 9.4 T. Furthermore, we demonstrate the effects of surface design of DyxFe3- xO4 NPs on their magnetic relaxivity and in vivo performance at UHF. The markedly enhanced r2/r1 of His-DyxFe3- xO4 NPs (x = 0.2) at 9.4 T is mainly attributed to decreased r1 relaxivity owing to the surface design and the possible disturbance of the Dy-Fe superexchange interaction. This work could provide an insightful strategy for the design of lanthanide-doped magnetic nanosystems as potential T2 MRI nanoprobes in UHF.

KW - Dysprosium

KW - Hierarchical surface structure

KW - Magnetic relaxivity

KW - Superparamagnetic iron oxide nanoparticles

KW - Ultra-high-field magnetic resonance imaging

UR - https://www.scopus.com/pages/publications/85065616237

U2 - 10.1016/j.jiec.2019.05.004

DO - 10.1016/j.jiec.2019.05.004

M3 - Article

AN - SCOPUS:85065616237

SN - 1226-086X

VL - 77

SP - 408

EP - 415

JO - Journal of Industrial and Engineering Chemistry

JF - Journal of Industrial and Engineering Chemistry

ER -

Improved magnetic relaxivity via hierarchical surface structure of dysprosium-engineered superparamagnetic iron oxide nanoparticles in ultra-high magnetic field

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this