Improvement of chiral separation efficiency through temperature control during one time high performance liquid chromatography analysis

Dan Bi Eun; Young Han Jeong; Jae Jeong Ryoo

doi:10.1002/chir.23444

Improvement of chiral separation efficiency through temperature control during one time high performance liquid chromatography analysis

Dan Bi Eun, Young Han Jeong, Jae Jeong Ryoo

Department of Chemical Science Education

Kyungpook National University

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

This study examined how manual temperature control affects the separation of two enantiomers of five racemic mixtures using high-performance liquid chromatography (HPLC) in terms of separation factor (α), resolution (Rs), and the number of theoretical plates (N). The results showed that heating/cooling during one time HPLC analysis improved the separation factor and resolution.

Original language	English
Pages (from-to)	941-947
Number of pages	7
Journal	Chirality
Volume	34
Issue number	7
DOIs	https://doi.org/10.1002/chir.23444
State	Published - Jul 2022

Keywords

chiral separation
HPLC
one time analysis
separation efficiency
temperature control

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10.1002/chir.23444

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abstract = "This study examined how manual temperature control affects the separation of two enantiomers of five racemic mixtures using high-performance liquid chromatography (HPLC) in terms of separation factor (α), resolution (Rs), and the number of theoretical plates (N). The results showed that heating/cooling during one time HPLC analysis improved the separation factor and resolution.",

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AB - This study examined how manual temperature control affects the separation of two enantiomers of five racemic mixtures using high-performance liquid chromatography (HPLC) in terms of separation factor (α), resolution (Rs), and the number of theoretical plates (N). The results showed that heating/cooling during one time HPLC analysis improved the separation factor and resolution.

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KW - HPLC

KW - one time analysis

KW - separation efficiency

KW - temperature control

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Improvement of chiral separation efficiency through temperature control during one time high performance liquid chromatography analysis

Abstract

Keywords

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