Improvement of chiral separation efficiency through temperature control during one time high performance liquid chromatography analysis

Dan Bi Eun; Young Han Jeong; Jae Jeong Ryoo

doi:10.1002/chir.23444

Improvement of chiral separation efficiency through temperature control during one time high performance liquid chromatography analysis

Dan Bi Eun
, Young Han Jeong
, Jae Jeong Ryoo

Department of Chemical Science Education

Kyungpook National University

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

This study examined how manual temperature control affects the separation of two enantiomers of five racemic mixtures using high-performance liquid chromatography (HPLC) in terms of separation factor (α), resolution (Rs), and the number of theoretical plates (N). The results showed that heating/cooling during one time HPLC analysis improved the separation factor and resolution.

Original language	English
Pages (from-to)	941-947
Number of pages	7
Journal	Chirality
Volume	34
Issue number	7
DOIs	https://doi.org/10.1002/chir.23444
State	Published - Jul 2022

Keywords

chiral separation
HPLC
one time analysis
separation efficiency
temperature control

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10.1002/chir.23444

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title = "Improvement of chiral separation efficiency through temperature control during one time high performance liquid chromatography analysis",

abstract = "This study examined how manual temperature control affects the separation of two enantiomers of five racemic mixtures using high-performance liquid chromatography (HPLC) in terms of separation factor (α), resolution (Rs), and the number of theoretical plates (N). The results showed that heating/cooling during one time HPLC analysis improved the separation factor and resolution.",

keywords = "chiral separation, HPLC, one time analysis, separation efficiency, temperature control",

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year = "2022",

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AU - Jeong, Young Han

AU - Ryoo, Jae Jeong

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N2 - This study examined how manual temperature control affects the separation of two enantiomers of five racemic mixtures using high-performance liquid chromatography (HPLC) in terms of separation factor (α), resolution (Rs), and the number of theoretical plates (N). The results showed that heating/cooling during one time HPLC analysis improved the separation factor and resolution.

AB - This study examined how manual temperature control affects the separation of two enantiomers of five racemic mixtures using high-performance liquid chromatography (HPLC) in terms of separation factor (α), resolution (Rs), and the number of theoretical plates (N). The results showed that heating/cooling during one time HPLC analysis improved the separation factor and resolution.

KW - chiral separation

KW - HPLC

KW - one time analysis

KW - separation efficiency

KW - temperature control

UR - https://www.scopus.com/pages/publications/85127162668

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DO - 10.1002/chir.23444

M3 - Article

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EP - 947

JO - Chirality

JF - Chirality

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ER -

Improvement of chiral separation efficiency through temperature control during one time high performance liquid chromatography analysis

Abstract

Keywords

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