In vitro and in vivo activities of SM-101, a mixture of metampicillin and sulbactam

Keum Hwa Choi; Sook Kyung Kim; Moon Chang Baek; Byong Kak Kim; Dong Young Lee; Eung Chil Choi

doi:10.1007/BF02976346

In vitro and in vivo activities of SM-101, a mixture of metampicillin and sulbactam

Keum Hwa Choi, Sook Kyung Kim, Moon Chang Baek, Byong Kak Kim, Dong Young Lee, Eung Chil Choi

Department of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

SM-101 is a mixture of metampicillin and sulbactam(2∶1). The antibacterial activities of SM-101 were compared with those of metampicillin, piperacillin and Augmentin. It showed powerful antibacterial activities against major strains. Except P. aeruginosa and S. marcescens, the in vitro antibacterial activity of SM-101 was higher than those of metampicillin, piperacillin and Augmentin against Staphylococcus spp., Streptococcus spp., Morganella morganii, E. coli, and Proteus spp. The ED₅₀ values of SM-101 were two-fold or greater than those of metampicillin, piperacillin and Augmentin against β-lactamase producing strains, P. mirabilis GN 79 and M. morganii MB4-11. The in vivo efficacy of SM-101 was more active than metampicillin and piperacillin and similar to Augmentin against S. aureus Smith, E. coli MB4-01 and K. pneumoniae MB4-02.

Original language	English
Pages (from-to)	423-426
Number of pages	4
Journal	Archives of Pharmacal Research
Volume	18
Issue number	6
DOIs	https://doi.org/10.1007/BF02976346
State	Published - Dec 1995

Keywords

Antibacterial activity
ED50
Lactamase
Metampicillin
SM-101
Sulbactam

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title = "In vitro and in vivo activities of SM-101, a mixture of metampicillin and sulbactam",

abstract = "SM-101 is a mixture of metampicillin and sulbactam(2∶1). The antibacterial activities of SM-101 were compared with those of metampicillin, piperacillin and Augmentin. It showed powerful antibacterial activities against major strains. Except P. aeruginosa and S. marcescens, the in vitro antibacterial activity of SM-101 was higher than those of metampicillin, piperacillin and Augmentin against Staphylococcus spp., Streptococcus spp., Morganella morganii, E. coli, and Proteus spp. The ED50 values of SM-101 were two-fold or greater than those of metampicillin, piperacillin and Augmentin against β-lactamase producing strains, P. mirabilis GN 79 and M. morganii MB4-11. The in vivo efficacy of SM-101 was more active than metampicillin and piperacillin and similar to Augmentin against S. aureus Smith, E. coli MB4-01 and K. pneumoniae MB4-02.",

keywords = "Antibacterial activity, ED50, Lactamase, Metampicillin, SM-101, Sulbactam",

author = "Choi, {Keum Hwa} and Kim, {Sook Kyung} and Baek, {Moon Chang} and Kim, {Byong Kak} and Lee, {Dong Young} and Choi, {Eung Chil}",

year = "1995",

month = dec,

doi = "10.1007/BF02976346",

language = "English",

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pages = "423--426",

journal = "Archives of Pharmacal Research",

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T1 - In vitro and in vivo activities of SM-101, a mixture of metampicillin and sulbactam

AU - Choi, Keum Hwa

AU - Kim, Sook Kyung

AU - Baek, Moon Chang

AU - Kim, Byong Kak

AU - Lee, Dong Young

AU - Choi, Eung Chil

PY - 1995/12

Y1 - 1995/12

N2 - SM-101 is a mixture of metampicillin and sulbactam(2∶1). The antibacterial activities of SM-101 were compared with those of metampicillin, piperacillin and Augmentin. It showed powerful antibacterial activities against major strains. Except P. aeruginosa and S. marcescens, the in vitro antibacterial activity of SM-101 was higher than those of metampicillin, piperacillin and Augmentin against Staphylococcus spp., Streptococcus spp., Morganella morganii, E. coli, and Proteus spp. The ED50 values of SM-101 were two-fold or greater than those of metampicillin, piperacillin and Augmentin against β-lactamase producing strains, P. mirabilis GN 79 and M. morganii MB4-11. The in vivo efficacy of SM-101 was more active than metampicillin and piperacillin and similar to Augmentin against S. aureus Smith, E. coli MB4-01 and K. pneumoniae MB4-02.

AB - SM-101 is a mixture of metampicillin and sulbactam(2∶1). The antibacterial activities of SM-101 were compared with those of metampicillin, piperacillin and Augmentin. It showed powerful antibacterial activities against major strains. Except P. aeruginosa and S. marcescens, the in vitro antibacterial activity of SM-101 was higher than those of metampicillin, piperacillin and Augmentin against Staphylococcus spp., Streptococcus spp., Morganella morganii, E. coli, and Proteus spp. The ED50 values of SM-101 were two-fold or greater than those of metampicillin, piperacillin and Augmentin against β-lactamase producing strains, P. mirabilis GN 79 and M. morganii MB4-11. The in vivo efficacy of SM-101 was more active than metampicillin and piperacillin and similar to Augmentin against S. aureus Smith, E. coli MB4-01 and K. pneumoniae MB4-02.

KW - Antibacterial activity

KW - ED50

KW - Lactamase

KW - Metampicillin

KW - SM-101

KW - Sulbactam

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U2 - 10.1007/BF02976346

DO - 10.1007/BF02976346

M3 - Article

AN - SCOPUS:0029554147

SN - 0253-6269

VL - 18

SP - 423

EP - 426

JO - Archives of Pharmacal Research

JF - Archives of Pharmacal Research

IS - 6

ER -

In vitro and in vivo activities of SM-101, a mixture of metampicillin and sulbactam

Abstract

Keywords

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