In vitro and in vivo antibacterial activities of DW-224a, a new fluoronaphthyridone

Hee Soo Park; Hyun Joo Kim; Min Jung Seol; Dong Rack Choi; Eung Chil Choi; Jin Hwan Kwak

doi:10.1128/AAC.01407-05

In vitro and in vivo antibacterial activities of DW-224a, a new fluoronaphthyridone

Hee Soo Park, Hyun Joo Kim, Min Jung Seol, Dong Rack Choi, Eung Chil Choi, Jin Hwan Kwak

School of Food Science & Biotechnology

Research output: Contribution to journal › Article › peer-review

54 Scopus citations

Abstract

DW-224a showed the most potent in vitro activity among the quinolone compounds tested against clinical isolates of gram-positive bacteria. Against gram-negative bacteria, DW-224a was slightly less active than the other fluoroquinolones. The in vivo activities of DW-224a against gram-positive bacteria were more potent than those of other quinolones.

Original language	English
Pages (from-to)	2261-2264
Number of pages	4
Journal	Antimicrobial Agents and Chemotherapy
Volume	50
Issue number	6
DOIs	https://doi.org/10.1128/AAC.01407-05
State	Published - Jun 2006

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10.1128/AAC.01407-05

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abstract = "DW-224a showed the most potent in vitro activity among the quinolone compounds tested against clinical isolates of gram-positive bacteria. Against gram-negative bacteria, DW-224a was slightly less active than the other fluoroquinolones. The in vivo activities of DW-224a against gram-positive bacteria were more potent than those of other quinolones.",

author = "Park, {Hee Soo} and Kim, {Hyun Joo} and Seol, {Min Jung} and Choi, {Dong Rack} and Choi, {Eung Chil} and Kwak, {Jin Hwan}",

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AU - Choi, Eung Chil

AU - Kwak, Jin Hwan

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AB - DW-224a showed the most potent in vitro activity among the quinolone compounds tested against clinical isolates of gram-positive bacteria. Against gram-negative bacteria, DW-224a was slightly less active than the other fluoroquinolones. The in vivo activities of DW-224a against gram-positive bacteria were more potent than those of other quinolones.

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In vitro and in vivo antibacterial activities of DW-224a, a new fluoronaphthyridone

Abstract

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