In vitro and in vivo antibacterial activities of DW-224a, a new fluoronaphthyridone

Hee Soo Park; Hyun Joo Kim; Min Jung Seol; Dong Rack Choi; Eung Chil Choi; Jin Hwan Kwak

doi:10.1128/AAC.01407-05

In vitro and in vivo antibacterial activities of DW-224a, a new fluoronaphthyridone

Hee Soo Park
, Hyun Joo Kim
, Min Jung Seol
, Dong Rack Choi
, Eung Chil Choi
, Jin Hwan Kwak

School of Food Science & Biotechnology

Handong Global University
Dong Wha Pharmaceutical Industry Co. Ltd.
Seoul National University

Research output: Contribution to journal › Article › peer-review

58 Scopus citations

Abstract

DW-224a showed the most potent in vitro activity among the quinolone compounds tested against clinical isolates of gram-positive bacteria. Against gram-negative bacteria, DW-224a was slightly less active than the other fluoroquinolones. The in vivo activities of DW-224a against gram-positive bacteria were more potent than those of other quinolones.

Original language	English
Pages (from-to)	2261-2264
Number of pages	4
Journal	Antimicrobial Agents and Chemotherapy
Volume	50
Issue number	6
DOIs	https://doi.org/10.1128/AAC.01407-05
State	Published - Jun 2006

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SDG 3 Good Health and Well-being

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10.1128/AAC.01407-05

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abstract = "DW-224a showed the most potent in vitro activity among the quinolone compounds tested against clinical isolates of gram-positive bacteria. Against gram-negative bacteria, DW-224a was slightly less active than the other fluoroquinolones. The in vivo activities of DW-224a against gram-positive bacteria were more potent than those of other quinolones.",

author = "Park, \{Hee Soo\} and Kim, \{Hyun Joo\} and Seol, \{Min Jung\} and Choi, \{Dong Rack\} and Choi, \{Eung Chil\} and Kwak, \{Jin Hwan\}",

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AU - Park, Hee Soo

AU - Kim, Hyun Joo

AU - Seol, Min Jung

AU - Choi, Dong Rack

AU - Choi, Eung Chil

AU - Kwak, Jin Hwan

PY - 2006/6

Y1 - 2006/6

N2 - DW-224a showed the most potent in vitro activity among the quinolone compounds tested against clinical isolates of gram-positive bacteria. Against gram-negative bacteria, DW-224a was slightly less active than the other fluoroquinolones. The in vivo activities of DW-224a against gram-positive bacteria were more potent than those of other quinolones.

AB - DW-224a showed the most potent in vitro activity among the quinolone compounds tested against clinical isolates of gram-positive bacteria. Against gram-negative bacteria, DW-224a was slightly less active than the other fluoroquinolones. The in vivo activities of DW-224a against gram-positive bacteria were more potent than those of other quinolones.

UR - https://www.scopus.com/pages/publications/33744464763

U2 - 10.1128/AAC.01407-05

DO - 10.1128/AAC.01407-05

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SN - 0066-4804

VL - 50

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EP - 2264

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

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ER -

In vitro and in vivo antibacterial activities of DW-224a, a new fluoronaphthyridone

Abstract

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