In vitro antimicrobial effects of silver nanoparticles on microorganisms isolated from dog with otitis external

Silver nanoparticles have marked antimicrobial effects on several pathogens and have been used to control bacterial growth in humans. In the present study, we evaluated the antimicrobial efficacy of silver nanoparticles against the common causative pathogens of canine otitis external through counting of colony forming units. Silver nanoparticles showed significant dose-dependent antimicrobial effects on pathogens. In addition, we conducted antimicrobial susceptibility tests and compared the antimicrobial efficacy of silver nanoparticles. Microorganisms with a high resistance to antibiotics were also resistant silver nanoparticle with low concentration (5 µg/mL). However, in high concentration (15 µg/mL), almost 100% reduction in the number of CFUs of these pathogens was observed.