In vitro apoptotic effect of cassaine-type diterpene amides from Erythrophleum fordii on PC-3 prostate cancer cells

Tran Manh Hung; To Dao Cuong; Jeong Ah Kim; Jeong Hyung Lee; Mi Hee Woo; Byung Sun Min

doi:10.1016/j.bmcl.2014.09.025

In vitro apoptotic effect of cassaine-type diterpene amides from Erythrophleum fordii on PC-3 prostate cancer cells

Tran Manh Hung
, To Dao Cuong
, Jeong Ah Kim
, Jeong Hyung Lee
, Mi Hee Woo
, Byung Sun Min

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Cytotoxic activity-guided fractionation of Erythrophleum fordii led to the isolation of two new cassaine diterpenoid-diterpenoid amide dimers, erythrophlesins H-I (1, 2). Spectral data indicated that they consist of asymmetrical dimeric structure via an ester bond between two cassaine diterpenoids. MTT assay confirmed that compound 1, erythrophlesin H, had the strongest cytotoxic effect toward the human prostate cancer cell line, PC-3. The molecular mechanism by which this compound induced apoptosis cell in prostate cancer remains unknown. Erythrophlesin H induced apoptosis in a dose-dependent manner. Acridine orange and annexin V-FITC/PI double staining confirmed that erythrophlesin H effectively induces apoptosis in PC-3 cells.

Original language	English
Pages (from-to)	4989-4994
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	24
Issue number	21
DOIs	https://doi.org/10.1016/j.bmcl.2014.09.025
State	Published - 1 Nov 2014

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Cassaine diterpenoid amide
Erythrophlesin H
Erythrophleum fordii
Leguminosae
PC-3 apoptosis

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10.1016/j.bmcl.2014.09.025

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@article{0b582ed305114f2f8b151d42880c8630,

title = "In vitro apoptotic effect of cassaine-type diterpene amides from Erythrophleum fordii on PC-3 prostate cancer cells",

abstract = "Cytotoxic activity-guided fractionation of Erythrophleum fordii led to the isolation of two new cassaine diterpenoid-diterpenoid amide dimers, erythrophlesins H-I (1, 2). Spectral data indicated that they consist of asymmetrical dimeric structure via an ester bond between two cassaine diterpenoids. MTT assay confirmed that compound 1, erythrophlesin H, had the strongest cytotoxic effect toward the human prostate cancer cell line, PC-3. The molecular mechanism by which this compound induced apoptosis cell in prostate cancer remains unknown. Erythrophlesin H induced apoptosis in a dose-dependent manner. Acridine orange and annexin V-FITC/PI double staining confirmed that erythrophlesin H effectively induces apoptosis in PC-3 cells.",

keywords = "Cassaine diterpenoid amide, Erythrophlesin H, Erythrophleum fordii, Leguminosae, PC-3 apoptosis",

author = "Hung, \{Tran Manh\} and Cuong, \{To Dao\} and Kim, \{Jeong Ah\} and Lee, \{Jeong Hyung\} and Woo, \{Mi Hee\} and Min, \{Byung Sun\}",

year = "2014",

month = nov,

day = "1",

doi = "10.1016/j.bmcl.2014.09.025",

language = "English",

volume = "24",

pages = "4989--4994",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier Ltd.",

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TY - JOUR

T1 - In vitro apoptotic effect of cassaine-type diterpene amides from Erythrophleum fordii on PC-3 prostate cancer cells

AU - Hung, Tran Manh

AU - Cuong, To Dao

AU - Kim, Jeong Ah

AU - Lee, Jeong Hyung

AU - Woo, Mi Hee

AU - Min, Byung Sun

PY - 2014/11/1

Y1 - 2014/11/1

N2 - Cytotoxic activity-guided fractionation of Erythrophleum fordii led to the isolation of two new cassaine diterpenoid-diterpenoid amide dimers, erythrophlesins H-I (1, 2). Spectral data indicated that they consist of asymmetrical dimeric structure via an ester bond between two cassaine diterpenoids. MTT assay confirmed that compound 1, erythrophlesin H, had the strongest cytotoxic effect toward the human prostate cancer cell line, PC-3. The molecular mechanism by which this compound induced apoptosis cell in prostate cancer remains unknown. Erythrophlesin H induced apoptosis in a dose-dependent manner. Acridine orange and annexin V-FITC/PI double staining confirmed that erythrophlesin H effectively induces apoptosis in PC-3 cells.

AB - Cytotoxic activity-guided fractionation of Erythrophleum fordii led to the isolation of two new cassaine diterpenoid-diterpenoid amide dimers, erythrophlesins H-I (1, 2). Spectral data indicated that they consist of asymmetrical dimeric structure via an ester bond between two cassaine diterpenoids. MTT assay confirmed that compound 1, erythrophlesin H, had the strongest cytotoxic effect toward the human prostate cancer cell line, PC-3. The molecular mechanism by which this compound induced apoptosis cell in prostate cancer remains unknown. Erythrophlesin H induced apoptosis in a dose-dependent manner. Acridine orange and annexin V-FITC/PI double staining confirmed that erythrophlesin H effectively induces apoptosis in PC-3 cells.

KW - Cassaine diterpenoid amide

KW - Erythrophlesin H

KW - Erythrophleum fordii

KW - Leguminosae

KW - PC-3 apoptosis

UR - https://www.scopus.com/pages/publications/84907963133

U2 - 10.1016/j.bmcl.2014.09.025

DO - 10.1016/j.bmcl.2014.09.025

M3 - Article

C2 - 25278231

AN - SCOPUS:84907963133

SN - 0960-894X

VL - 24

SP - 4989

EP - 4994

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 21

ER -

In vitro apoptotic effect of cassaine-type diterpene amides from Erythrophleum fordii on PC-3 prostate cancer cells

Abstract

UN SDGs

Keywords

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