In vitro evaluation of hydroxyapatite-coated titanium implant with atmospheric plasma treatment

Hyo Jin Lee; Tae Yub Kwon; Kyo Han Kim; Seong Soo Kang; Seok Hwa Choi; Soon Taek Kwon; Dae Hyun Cho; Jun Sik Son

doi:10.1166/jnn.2015.10455

In vitro evaluation of hydroxyapatite-coated titanium implant with atmospheric plasma treatment

Hyo Jin Lee, Tae Yub Kwon, Kyo Han Kim, Seong Soo Kang, Seok Hwa Choi, Soon Taek Kwon, Dae Hyun Cho, Jun Sik Son

Department of Dentistry

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Plasma treatments are becoming a popular method for modifying the characteristics of a range of substrate surfaces. Atmospheric pressure plasma (APP) is cost-efficient, safe and simple compared to high-pressure plasma. This study examined the effects of a low-temperature APP treatment of a hydroxyapatite (HA)-coated Ti (HA-Ti) surface. The APP treatment made the HA-Ti surfaces more hydrophilic without changing surface morphologies. The APP-treated HA-Ti (APP-HA-Ti) surface showed enhanced cell spreading, cell proliferation, and alkaline phosphatase (ALP) levels with more developed cellular networks, and the formed extracellular matrix (ECM) was fused perfectly with the HA substrate than that on the HA-Ti surface. In conclusion, an APP treatment is a potential surface-modifying method that can enhance the cell affinity at the early stages in vitro.

Original language	English
Pages (from-to)	5593-5596
Number of pages	4
Journal	Journal of Nanoscience and Nanotechnology
Volume	15
Issue number	8
DOIs	https://doi.org/10.1166/jnn.2015.10455
State	Published - 1 Jan 2015

Keywords

Activity
Atmospheric pressure plasma
Hydroxyapatite
Osteoblast
Titanium implant

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title = "In vitro evaluation of hydroxyapatite-coated titanium implant with atmospheric plasma treatment",

abstract = "Plasma treatments are becoming a popular method for modifying the characteristics of a range of substrate surfaces. Atmospheric pressure plasma (APP) is cost-efficient, safe and simple compared to high-pressure plasma. This study examined the effects of a low-temperature APP treatment of a hydroxyapatite (HA)-coated Ti (HA-Ti) surface. The APP treatment made the HA-Ti surfaces more hydrophilic without changing surface morphologies. The APP-treated HA-Ti (APP-HA-Ti) surface showed enhanced cell spreading, cell proliferation, and alkaline phosphatase (ALP) levels with more developed cellular networks, and the formed extracellular matrix (ECM) was fused perfectly with the HA substrate than that on the HA-Ti surface. In conclusion, an APP treatment is a potential surface-modifying method that can enhance the cell affinity at the early stages in vitro.",

keywords = "Activity, Atmospheric pressure plasma, Hydroxyapatite, Osteoblast, Titanium implant",

author = "Lee, {Hyo Jin} and Kwon, {Tae Yub} and Kim, {Kyo Han} and Kang, {Seong Soo} and Choi, {Seok Hwa} and Kwon, {Soon Taek} and Cho, {Dae Hyun} and Son, {Jun Sik}",

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AU - Lee, Hyo Jin

AU - Kwon, Tae Yub

AU - Kim, Kyo Han

AU - Kang, Seong Soo

AU - Choi, Seok Hwa

AU - Kwon, Soon Taek

AU - Cho, Dae Hyun

AU - Son, Jun Sik

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Plasma treatments are becoming a popular method for modifying the characteristics of a range of substrate surfaces. Atmospheric pressure plasma (APP) is cost-efficient, safe and simple compared to high-pressure plasma. This study examined the effects of a low-temperature APP treatment of a hydroxyapatite (HA)-coated Ti (HA-Ti) surface. The APP treatment made the HA-Ti surfaces more hydrophilic without changing surface morphologies. The APP-treated HA-Ti (APP-HA-Ti) surface showed enhanced cell spreading, cell proliferation, and alkaline phosphatase (ALP) levels with more developed cellular networks, and the formed extracellular matrix (ECM) was fused perfectly with the HA substrate than that on the HA-Ti surface. In conclusion, an APP treatment is a potential surface-modifying method that can enhance the cell affinity at the early stages in vitro.

AB - Plasma treatments are becoming a popular method for modifying the characteristics of a range of substrate surfaces. Atmospheric pressure plasma (APP) is cost-efficient, safe and simple compared to high-pressure plasma. This study examined the effects of a low-temperature APP treatment of a hydroxyapatite (HA)-coated Ti (HA-Ti) surface. The APP treatment made the HA-Ti surfaces more hydrophilic without changing surface morphologies. The APP-treated HA-Ti (APP-HA-Ti) surface showed enhanced cell spreading, cell proliferation, and alkaline phosphatase (ALP) levels with more developed cellular networks, and the formed extracellular matrix (ECM) was fused perfectly with the HA substrate than that on the HA-Ti surface. In conclusion, an APP treatment is a potential surface-modifying method that can enhance the cell affinity at the early stages in vitro.

KW - Activity

KW - Atmospheric pressure plasma

KW - Hydroxyapatite

KW - Osteoblast

KW - Titanium implant

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ER -

In vitro evaluation of hydroxyapatite-coated titanium implant with atmospheric plasma treatment

Abstract

Keywords

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