In vitro metabolism study of seongsanamide a in human liver microsomes using non-targeted metabolomics and feature-based molecular networking

Pharmacology, Toxicology and Pharmaceutical Science

• Cytochrome P450 100%
• Drug Interaction 100%
• Antiallergic 50%
• Cytotoxicity 50%
• Bacilli 50%
• Cytochrome P450 3A5 50%
• CYP3A4 50%
• Digestant 50%
• Drug Metabolism 50%
• IC50 50%

Biochemistry, Genetics and Molecular Biology

• Metabolomics 100%
• Metabolic Pathway 100%
• Metabolite 40%
• Drug Interaction 40%
• Isoform 40%
• Cytochrome P450 40%
• Drug Metabolism 20%
• Enzyme 20%
• Bacilli 20%
• Phenotype 20%
• Enzymatic Hydrolysis 20%
• IC50 20%
• CYP3A5 20%
• Cytotoxicity 20%

Chemistry

• Metabolic 100%
• Metabolite 66%
• Cytochrome P450 66%
• IC50 33%
• Tandem Mass Spectrum 33%
• Antiallergic 33%