Abstract
Ultrasmall nanoparticles are potential candidates for application as high-performance imaging agents. Herein, we present the synthesis and characterization of folic acid (FA)-conjugated polyacrylic acid (PAA)-coated MnO nanoparticles with an average particle diameter of 2.7 nm. FA conferred cancer-targeting ability, while PAA conferred good colloidal stability and low cellular cytotoxicity on the FA-PAA-coated MnO nanoparticles. Further, the nanoparticles exhibited a high relaxivity (r1) value of 9.3 s−1mM−1 (r2/r1 = 2.2). Their application potential as cancer-targeting T1 magnetic resonance imaging contrast agents was confirmed by their enhanced T1 contrast enhance-ments at the brain cancer (U87MG) site upon intravenous administration to mice tails.
Original language | English |
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Article number | 2596 |
Journal | Applied Sciences (Switzerland) |
Volume | 11 |
Issue number | 6 |
DOIs | |
State | Published - 2 Mar 2021 |
Keywords
- Brain cancer
- Cancer targeting
- Folic acid
- Magnetic resonance imaging
- Ultrasmall manganese oxide nanoparticles