In vivo positive magnetic resonance imaging of brain cancer (U87MG) using folic acid-conjugated polyacrylic acid-coated ultrasmall manganese oxide nanoparticles

Shanti Marasini, Huan Yue, Son Long Ho, Ji Ae Park, Soyeon Kim, Ji Ung Yang, Hyunsil Cha, Shuwen Liu, Tirusew Tegafaw, Mohammad Yaseen Ahmad, Abdullah Khamis Ali Al Saidi, Dejun Zhao, Ying Liu, Kwon Seok Chae, Yongmin Chang, Gang Ho Lee

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10 Scopus citations

Abstract

Ultrasmall nanoparticles are potential candidates for application as high-performance imaging agents. Herein, we present the synthesis and characterization of folic acid (FA)-conjugated polyacrylic acid (PAA)-coated MnO nanoparticles with an average particle diameter of 2.7 nm. FA conferred cancer-targeting ability, while PAA conferred good colloidal stability and low cellular cytotoxicity on the FA-PAA-coated MnO nanoparticles. Further, the nanoparticles exhibited a high relaxivity (r1) value of 9.3 s−1mM−1 (r2/r1 = 2.2). Their application potential as cancer-targeting T1 magnetic resonance imaging contrast agents was confirmed by their enhanced T1 contrast enhance-ments at the brain cancer (U87MG) site upon intravenous administration to mice tails.

Original languageEnglish
Article number2596
JournalApplied Sciences (Switzerland)
Volume11
Issue number6
DOIs
StatePublished - 2 Mar 2021

Keywords

  • Brain cancer
  • Cancer targeting
  • Folic acid
  • Magnetic resonance imaging
  • Ultrasmall manganese oxide nanoparticles

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