In vivo positive magnetic resonance imaging of brain cancer (U87MG) using folic acid-conjugated polyacrylic acid-coated ultrasmall manganese oxide nanoparticles

Shanti Marasini; Huan Yue; Son Long Ho; Ji Ae Park; Soyeon Kim; Ji Ung Yang; Hyunsil Cha; Shuwen Liu; Tirusew Tegafaw; Mohammad Yaseen Ahmad; Abdullah Khamis Ali Al Saidi; Dejun Zhao; Ying Liu; Kwon Seok Chae; Yongmin Chang; Gang Ho Lee

doi:10.3390/app11062596

In vivo positive magnetic resonance imaging of brain cancer (U87MG) using folic acid-conjugated polyacrylic acid-coated ultrasmall manganese oxide nanoparticles

Shanti Marasini
, Huan Yue
, Son Long Ho
, Ji Ae Park
, Soyeon Kim
, Ji Ung Yang
, Hyunsil Cha
, Shuwen Liu
, Tirusew Tegafaw
, Mohammad Yaseen Ahmad
, Abdullah Khamis Ali Al Saidi
, Dejun Zhao
, Ying Liu
, Kwon Seok Chae
, Yongmin Chang
, Gang Ho Lee

Kyungpook National University
Korea Institute of Radiological and Medical Sciences

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Ultrasmall nanoparticles are potential candidates for application as high-performance imaging agents. Herein, we present the synthesis and characterization of folic acid (FA)-conjugated polyacrylic acid (PAA)-coated MnO nanoparticles with an average particle diameter of 2.7 nm. FA conferred cancer-targeting ability, while PAA conferred good colloidal stability and low cellular cytotoxicity on the FA-PAA-coated MnO nanoparticles. Further, the nanoparticles exhibited a high relaxivity (r₁) value of 9.3 s⁻¹mM⁻¹ (r₂/r₁ = 2.2). Their application potential as cancer-targeting T₁ magnetic resonance imaging contrast agents was confirmed by their enhanced T₁ contrast enhance-ments at the brain cancer (U87MG) site upon intravenous administration to mice tails.

Original language	English
Article number	2596
Journal	Applied Sciences (Switzerland)
Volume	11
Issue number	6
DOIs	https://doi.org/10.3390/app11062596
State	Published - 2 Mar 2021

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Brain cancer
Cancer targeting
Folic acid
Magnetic resonance imaging
Ultrasmall manganese oxide nanoparticles

Access to Document

10.3390/app11062596

Cite this

Marasini, S., Yue, H., Ho, S. L., Park, J. A., Kim, S., Yang, J. U., Cha, H., Liu, S., Tegafaw, T., Ahmad, M. Y., Al Saidi, A. K. A., Zhao, D., Liu, Y., Chae, K. S., Chang, Y., & Lee, G. H. (2021). In vivo positive magnetic resonance imaging of brain cancer (U87MG) using folic acid-conjugated polyacrylic acid-coated ultrasmall manganese oxide nanoparticles. Applied Sciences (Switzerland), 11(6), Article 2596. https://doi.org/10.3390/app11062596

@article{aab11de6d474472bbe6958a5cc419c03,

title = "In vivo positive magnetic resonance imaging of brain cancer (U87MG) using folic acid-conjugated polyacrylic acid-coated ultrasmall manganese oxide nanoparticles",

abstract = "Ultrasmall nanoparticles are potential candidates for application as high-performance imaging agents. Herein, we present the synthesis and characterization of folic acid (FA)-conjugated polyacrylic acid (PAA)-coated MnO nanoparticles with an average particle diameter of 2.7 nm. FA conferred cancer-targeting ability, while PAA conferred good colloidal stability and low cellular cytotoxicity on the FA-PAA-coated MnO nanoparticles. Further, the nanoparticles exhibited a high relaxivity (r1) value of 9.3 s−1mM−1 (r2/r1 = 2.2). Their application potential as cancer-targeting T1 magnetic resonance imaging contrast agents was confirmed by their enhanced T1 contrast enhance-ments at the brain cancer (U87MG) site upon intravenous administration to mice tails.",

keywords = "Brain cancer, Cancer targeting, Folic acid, Magnetic resonance imaging, Ultrasmall manganese oxide nanoparticles",

author = "Shanti Marasini and Huan Yue and Ho, \{Son Long\} and Park, \{Ji Ae\} and Soyeon Kim and Yang, \{Ji Ung\} and Hyunsil Cha and Shuwen Liu and Tirusew Tegafaw and Ahmad, \{Mohammad Yaseen\} and \{Al Saidi\}, \{Abdullah Khamis Ali\} and Dejun Zhao and Ying Liu and Chae, \{Kwon Seok\} and Yongmin Chang and Lee, \{Gang Ho\}",

note = "Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2021",

month = mar,

day = "2",

doi = "10.3390/app11062596",

language = "English",

volume = "11",

journal = "Applied Sciences (Switzerland)",

issn = "2076-3417",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "6",

}

Marasini, S, Yue, H, Ho, SL, Park, JA, Kim, S, Yang, JU, Cha, H, Liu, S, Tegafaw, T, Ahmad, MY, Al Saidi, AKA, Zhao, D, Liu, Y, Chae, KS , Chang, Y & Lee, GH 2021, 'In vivo positive magnetic resonance imaging of brain cancer (U87MG) using folic acid-conjugated polyacrylic acid-coated ultrasmall manganese oxide nanoparticles', Applied Sciences (Switzerland), vol. 11, no. 6, 2596. https://doi.org/10.3390/app11062596

TY - JOUR

T1 - In vivo positive magnetic resonance imaging of brain cancer (U87MG) using folic acid-conjugated polyacrylic acid-coated ultrasmall manganese oxide nanoparticles

AU - Marasini, Shanti

AU - Yue, Huan

AU - Ho, Son Long

AU - Park, Ji Ae

AU - Kim, Soyeon

AU - Yang, Ji Ung

AU - Cha, Hyunsil

AU - Liu, Shuwen

AU - Tegafaw, Tirusew

AU - Ahmad, Mohammad Yaseen

AU - Al Saidi, Abdullah Khamis Ali

AU - Zhao, Dejun

AU - Liu, Ying

AU - Chae, Kwon Seok

AU - Chang, Yongmin

AU - Lee, Gang Ho

PY - 2021/3/2

Y1 - 2021/3/2

N2 - Ultrasmall nanoparticles are potential candidates for application as high-performance imaging agents. Herein, we present the synthesis and characterization of folic acid (FA)-conjugated polyacrylic acid (PAA)-coated MnO nanoparticles with an average particle diameter of 2.7 nm. FA conferred cancer-targeting ability, while PAA conferred good colloidal stability and low cellular cytotoxicity on the FA-PAA-coated MnO nanoparticles. Further, the nanoparticles exhibited a high relaxivity (r1) value of 9.3 s−1mM−1 (r2/r1 = 2.2). Their application potential as cancer-targeting T1 magnetic resonance imaging contrast agents was confirmed by their enhanced T1 contrast enhance-ments at the brain cancer (U87MG) site upon intravenous administration to mice tails.

AB - Ultrasmall nanoparticles are potential candidates for application as high-performance imaging agents. Herein, we present the synthesis and characterization of folic acid (FA)-conjugated polyacrylic acid (PAA)-coated MnO nanoparticles with an average particle diameter of 2.7 nm. FA conferred cancer-targeting ability, while PAA conferred good colloidal stability and low cellular cytotoxicity on the FA-PAA-coated MnO nanoparticles. Further, the nanoparticles exhibited a high relaxivity (r1) value of 9.3 s−1mM−1 (r2/r1 = 2.2). Their application potential as cancer-targeting T1 magnetic resonance imaging contrast agents was confirmed by their enhanced T1 contrast enhance-ments at the brain cancer (U87MG) site upon intravenous administration to mice tails.

KW - Brain cancer

KW - Cancer targeting

KW - Folic acid

KW - Magnetic resonance imaging

KW - Ultrasmall manganese oxide nanoparticles

UR - https://www.scopus.com/pages/publications/85103256882

U2 - 10.3390/app11062596

DO - 10.3390/app11062596

M3 - Article

AN - SCOPUS:85103256882

SN - 2076-3417

VL - 11

JO - Applied Sciences (Switzerland)

JF - Applied Sciences (Switzerland)

IS - 6

M1 - 2596

ER -

In vivo positive magnetic resonance imaging of brain cancer (U87MG) using folic acid-conjugated polyacrylic acid-coated ultrasmall manganese oxide nanoparticles

Abstract

UN SDGs

Keywords

Access to Document

Other files and links

Fingerprint

Cite this