In-vivo sonothrombolysis with a forward-viewing ultrasound balloon catheter in a swine deep vein thrombosis (DVT) model

Huaiyu Wu; Bohua Zhang; Jinwook Kim; Gabe Owens; Greyson Stocker; Mengyue Chen; Ashley Cornett; Kathlyne Bautista; Paul A. Dayton; Zhen Xu; Xiaoning Jiang

doi:10.1109/IUS51837.2023.10307303

In-vivo sonothrombolysis with a forward-viewing ultrasound balloon catheter in a swine deep vein thrombosis (DVT) model

Huaiyu Wu, Bohua Zhang, Jinwook Kim, Gabe Owens, Greyson Stocker, Mengyue Chen, Ashley Cornett, Kathlyne Bautista, Paul A. Dayton, Zhen Xu, Xiaoning Jiang

School of Mechanical Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

Thrombosis has emerged as one of the foremost global causes of death. However, the currently available thrombolysis techniques, such as fibrinolytic agent administration and mechanical thrombectomy, are associated with prolonged treatment duration and an increased risk of hemorrhage. Here we present our development of a novel 9 Fr intravascular forward-viewing sonothrombolysis balloon catheter and initial in-vivo testing in a swine DVT model. The balloon was designed to expand during treatment, improving transducer alignment with the clot and enhancing catheter visualization under ultrasound guidance. The forward-viewing configuration enables thrombolysis of both partial and completely occluded clots, which created a flow channel of 2-2.5 mm diameter through all four completely occluded acute clots of ~2cm long in 30 minutes in-vivo.

Original language	English
Title of host publication	IUS 2023 - IEEE International Ultrasonics Symposium, Proceedings
Publisher	IEEE Computer Society
ISBN (Electronic)	9798350346459
DOIs	https://doi.org/10.1109/IUS51837.2023.10307303
State	Published - 2023
Event	2023 IEEE International Ultrasonics Symposium, IUS 2023 - Montreal, Canada Duration: 3 Sep 2023 → 8 Sep 2023

Publication series

Name	IEEE International Ultrasonics Symposium, IUS
ISSN (Print)	1948-5719
ISSN (Electronic)	1948-5727

Conference

Conference	2023 IEEE International Ultrasonics Symposium, IUS 2023
Country/Territory	Canada
City	Montreal
Period	3/09/23 → 8/09/23

Keywords

In-vivo sonothrombolysis
Intravascular transducer

Access to Document

10.1109/IUS51837.2023.10307303

Cite this

Wu, H., Zhang, B., Kim, J., Owens, G., Stocker, G., Chen, M., Cornett, A., Bautista, K., Dayton, P. A., Xu, Z., & Jiang, X. (2023). In-vivo sonothrombolysis with a forward-viewing ultrasound balloon catheter in a swine deep vein thrombosis (DVT) model. In IUS 2023 - IEEE International Ultrasonics Symposium, Proceedings (IEEE International Ultrasonics Symposium, IUS). IEEE Computer Society. https://doi.org/10.1109/IUS51837.2023.10307303

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title = "In-vivo sonothrombolysis with a forward-viewing ultrasound balloon catheter in a swine deep vein thrombosis (DVT) model",

abstract = "Thrombosis has emerged as one of the foremost global causes of death. However, the currently available thrombolysis techniques, such as fibrinolytic agent administration and mechanical thrombectomy, are associated with prolonged treatment duration and an increased risk of hemorrhage. Here we present our development of a novel 9 Fr intravascular forward-viewing sonothrombolysis balloon catheter and initial in-vivo testing in a swine DVT model. The balloon was designed to expand during treatment, improving transducer alignment with the clot and enhancing catheter visualization under ultrasound guidance. The forward-viewing configuration enables thrombolysis of both partial and completely occluded clots, which created a flow channel of 2-2.5 mm diameter through all four completely occluded acute clots of ~2cm long in 30 minutes in-vivo.",

keywords = "In-vivo sonothrombolysis, Intravascular transducer",

author = "Huaiyu Wu and Bohua Zhang and Jinwook Kim and Gabe Owens and Greyson Stocker and Mengyue Chen and Ashley Cornett and Kathlyne Bautista and Dayton, {Paul A.} and Zhen Xu and Xiaoning Jiang",

note = "Publisher Copyright: {\textcopyright} 2023 IEEE.; 2023 IEEE International Ultrasonics Symposium, IUS 2023 ; Conference date: 03-09-2023 Through 08-09-2023",

year = "2023",

doi = "10.1109/IUS51837.2023.10307303",

language = "English",

series = "IEEE International Ultrasonics Symposium, IUS",

publisher = "IEEE Computer Society",

booktitle = "IUS 2023 - IEEE International Ultrasonics Symposium, Proceedings",

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Wu, H, Zhang, B, Kim, J, Owens, G, Stocker, G, Chen, M, Cornett, A, Bautista, K, Dayton, PA, Xu, Z & Jiang, X 2023, In-vivo sonothrombolysis with a forward-viewing ultrasound balloon catheter in a swine deep vein thrombosis (DVT) model. in IUS 2023 - IEEE International Ultrasonics Symposium, Proceedings. IEEE International Ultrasonics Symposium, IUS, IEEE Computer Society, 2023 IEEE International Ultrasonics Symposium, IUS 2023, Montreal, Canada, 3/09/23. https://doi.org/10.1109/IUS51837.2023.10307303

In-vivo sonothrombolysis with a forward-viewing ultrasound balloon catheter in a swine deep vein thrombosis (DVT) model. / Wu, Huaiyu; Zhang, Bohua; Kim, Jinwook et al.
IUS 2023 - IEEE International Ultrasonics Symposium, Proceedings. IEEE Computer Society, 2023. (IEEE International Ultrasonics Symposium, IUS).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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AU - Stocker, Greyson

AU - Chen, Mengyue

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AU - Bautista, Kathlyne

AU - Dayton, Paul A.

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AB - Thrombosis has emerged as one of the foremost global causes of death. However, the currently available thrombolysis techniques, such as fibrinolytic agent administration and mechanical thrombectomy, are associated with prolonged treatment duration and an increased risk of hemorrhage. Here we present our development of a novel 9 Fr intravascular forward-viewing sonothrombolysis balloon catheter and initial in-vivo testing in a swine DVT model. The balloon was designed to expand during treatment, improving transducer alignment with the clot and enhancing catheter visualization under ultrasound guidance. The forward-viewing configuration enables thrombolysis of both partial and completely occluded clots, which created a flow channel of 2-2.5 mm diameter through all four completely occluded acute clots of ~2cm long in 30 minutes in-vivo.

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In-vivo sonothrombolysis with a forward-viewing ultrasound balloon catheter in a swine deep vein thrombosis (DVT) model

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