TY - JOUR
T1 - Induction of inflammatory cytokines and toll-like receptors in chickens infected with avian H9N2 influenza virus
AU - Nang, Nguyen
AU - Lee, Joo
AU - Song, Byung
AU - Kang, Young
AU - Kim, Hyun
AU - Seo, Sang
PY - 2011
Y1 - 2011
N2 - H9N2 influenza virus is endemic in many Asian countries and is regarded as a candidate for the next human pandemic. Knowledge of the induction of inflammatory responses and toll-like receptors (TLRs) in chickens infected with H9N2 is limited. Here, we show that H9N2 induces pro-inflammatory cytokines such as transforming growth factor-beta 3; tumor necrosis factor-alpha; interferon-alpha, -beta, and gamma; and TLR 1, 2, 3, 4, 5, 7, and 15 in trachea, lung, and intestine of infected chickens. In the lung, TLR-15 was dominantly induced. Taken together, it seems that H9N2 infections efficiently induce inflammatory cytokines and TLRs in trachea, lung and intestine of chickens.
AB - H9N2 influenza virus is endemic in many Asian countries and is regarded as a candidate for the next human pandemic. Knowledge of the induction of inflammatory responses and toll-like receptors (TLRs) in chickens infected with H9N2 is limited. Here, we show that H9N2 induces pro-inflammatory cytokines such as transforming growth factor-beta 3; tumor necrosis factor-alpha; interferon-alpha, -beta, and gamma; and TLR 1, 2, 3, 4, 5, 7, and 15 in trachea, lung, and intestine of infected chickens. In the lung, TLR-15 was dominantly induced. Taken together, it seems that H9N2 infections efficiently induce inflammatory cytokines and TLRs in trachea, lung and intestine of chickens.
UR - http://www.scopus.com/inward/record.url?scp=80052009521&partnerID=8YFLogxK
U2 - 10.1186/1297-9716-42-64
DO - 10.1186/1297-9716-42-64
M3 - Article
C2 - 21592354
AN - SCOPUS:80052009521
SN - 0928-4249
VL - 42
JO - Veterinary Research
JF - Veterinary Research
IS - 1
M1 - 64
ER -