Inhibition of FoxO1 acetylation by INHAT subunit SET/TAF-Iβ induces p21 transcription

Yun Cheol Chae; Kee Beom Kim; Joo Young Kang; Se Ryeon Kim; Hyeon Soo Jung; Sang Beom Seo

doi:10.1016/j.febslet.2014.06.053

Inhibition of FoxO1 acetylation by INHAT subunit SET/TAF-Iβ induces p21 transcription

Yun Cheol Chae, Kee Beom Kim, Joo Young Kang, Se Ryeon Kim, Hyeon Soo Jung, Sang Beom Seo

Chung-Ang University

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

Post-translational modification of forkhead family transcription factor, FoxO1, is an important regulatory mode for its diverse activities. FoxO1 is acetylated by HAT coactivators and its transcriptional activity is decreased via reduced DNA binding affinity. Here, we report that SET/TAF-Iβ inhibited p300-mediated FoxO1 acetylation in an INHAT domain-dependent manner. SET/TAF-Iβ interacted with FoxO1 and activated transcription of FoxO1 target gene, p21. Moreover, SET/TAF-Iβ inhibited acetylation of FoxO1 and increased p21 transcription induced by oxidative stress. Our results suggest that SET/TAF-Iβ inhibits FoxO1 acetylation and activates its transcriptional activity toward p21.

Original language	English
Pages (from-to)	2867-2873
Number of pages	7
Journal	FEBS Letters
Volume	588
Issue number	17
DOIs	https://doi.org/10.1016/j.febslet.2014.06.053
State	Published - 25 Aug 2014

Keywords

Acetylation
FoxO1
p21
SET/TAF-Iβ
Transcription

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10.1016/j.febslet.2014.06.053

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title = "Inhibition of FoxO1 acetylation by INHAT subunit SET/TAF-Iβ induces p21 transcription",

abstract = "Post-translational modification of forkhead family transcription factor, FoxO1, is an important regulatory mode for its diverse activities. FoxO1 is acetylated by HAT coactivators and its transcriptional activity is decreased via reduced DNA binding affinity. Here, we report that SET/TAF-Iβ inhibited p300-mediated FoxO1 acetylation in an INHAT domain-dependent manner. SET/TAF-Iβ interacted with FoxO1 and activated transcription of FoxO1 target gene, p21. Moreover, SET/TAF-Iβ inhibited acetylation of FoxO1 and increased p21 transcription induced by oxidative stress. Our results suggest that SET/TAF-Iβ inhibits FoxO1 acetylation and activates its transcriptional activity toward p21.",

keywords = "Acetylation, FoxO1, p21, SET/TAF-Iβ, Transcription",

author = "Chae, {Yun Cheol} and Kim, {Kee Beom} and Kang, {Joo Young} and Kim, {Se Ryeon} and Jung, {Hyeon Soo} and Seo, {Sang Beom}",

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T1 - Inhibition of FoxO1 acetylation by INHAT subunit SET/TAF-Iβ induces p21 transcription

AU - Chae, Yun Cheol

AU - Kim, Kee Beom

AU - Kang, Joo Young

AU - Kim, Se Ryeon

AU - Jung, Hyeon Soo

AU - Seo, Sang Beom

PY - 2014/8/25

Y1 - 2014/8/25

N2 - Post-translational modification of forkhead family transcription factor, FoxO1, is an important regulatory mode for its diverse activities. FoxO1 is acetylated by HAT coactivators and its transcriptional activity is decreased via reduced DNA binding affinity. Here, we report that SET/TAF-Iβ inhibited p300-mediated FoxO1 acetylation in an INHAT domain-dependent manner. SET/TAF-Iβ interacted with FoxO1 and activated transcription of FoxO1 target gene, p21. Moreover, SET/TAF-Iβ inhibited acetylation of FoxO1 and increased p21 transcription induced by oxidative stress. Our results suggest that SET/TAF-Iβ inhibits FoxO1 acetylation and activates its transcriptional activity toward p21.

AB - Post-translational modification of forkhead family transcription factor, FoxO1, is an important regulatory mode for its diverse activities. FoxO1 is acetylated by HAT coactivators and its transcriptional activity is decreased via reduced DNA binding affinity. Here, we report that SET/TAF-Iβ inhibited p300-mediated FoxO1 acetylation in an INHAT domain-dependent manner. SET/TAF-Iβ interacted with FoxO1 and activated transcription of FoxO1 target gene, p21. Moreover, SET/TAF-Iβ inhibited acetylation of FoxO1 and increased p21 transcription induced by oxidative stress. Our results suggest that SET/TAF-Iβ inhibits FoxO1 acetylation and activates its transcriptional activity toward p21.

KW - Acetylation

KW - FoxO1

KW - p21

KW - SET/TAF-Iβ

KW - Transcription

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DO - 10.1016/j.febslet.2014.06.053

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SN - 0014-5793

VL - 588

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EP - 2873

JO - FEBS Letters

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IS - 17

ER -

Inhibition of FoxO1 acetylation by INHAT subunit SET/TAF-Iβ induces p21 transcription

Abstract

Keywords

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