Inhibition of Glutamine Utilization Synergizes with Immune Checkpoint Inhibitor to Promote Antitumor Immunity

Jun Kyu Byun; Mihyang Park; Seunghyeong Lee; Jae Won Yun; Jaebon Lee; Jae Sun Kim; Sung Jin Cho; Hui Jeon Jeon; In Kyu Lee; Yeon Kyung Choi; Keun Gyu Park

doi:10.1016/j.molcel.2020.10.015

Inhibition of Glutamine Utilization Synergizes with Immune Checkpoint Inhibitor to Promote Antitumor Immunity

Jun Kyu Byun, Mihyang Park, Seunghyeong Lee, Jae Won Yun, Jaebon Lee, Jae Sun Kim, Sung Jin Cho, Hui Jeon Jeon, In Kyu Lee, Yeon Kyung Choi, Keun Gyu Park

Research output: Contribution to journal › Article › peer-review

141 Scopus citations

Abstract

Byun et al. demonstrated that upregulation of PD-L1 expression in cancer cells in a glutamine-poor tumor microenvironment dampens the antitumor properties of T cells, even though Fas-induced apoptosis signaling is upregulated. However, combined treatment with an inhibitor of glutamine utilization and anti-PD-L1 antibody significantly increased T-cell-mediated cancer cell death.

Original language	English
Pages (from-to)	592-606.e8
Journal	Molecular Cell
Volume	80
Issue number	4
DOIs	https://doi.org/10.1016/j.molcel.2020.10.015
State	Published - 19 Nov 2020

Keywords

PD-L1
SERCA
antitumor immunity
glutamine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.molcel.2020.10.015

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title = "Inhibition of Glutamine Utilization Synergizes with Immune Checkpoint Inhibitor to Promote Antitumor Immunity",

abstract = "Byun et al. demonstrated that upregulation of PD-L1 expression in cancer cells in a glutamine-poor tumor microenvironment dampens the antitumor properties of T cells, even though Fas-induced apoptosis signaling is upregulated. However, combined treatment with an inhibitor of glutamine utilization and anti-PD-L1 antibody significantly increased T-cell-mediated cancer cell death.",

keywords = "PD-L1, SERCA, antitumor immunity, glutamine",

author = "Byun, {Jun Kyu} and Mihyang Park and Seunghyeong Lee and Yun, {Jae Won} and Jaebon Lee and Kim, {Jae Sun} and Cho, {Sung Jin} and Jeon, {Hui Jeon} and Lee, {In Kyu} and Choi, {Yeon Kyung} and Park, {Keun Gyu}",

note = "Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",

year = "2020",

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day = "19",

doi = "10.1016/j.molcel.2020.10.015",

language = "English",

volume = "80",

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journal = "Molecular Cell",

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T1 - Inhibition of Glutamine Utilization Synergizes with Immune Checkpoint Inhibitor to Promote Antitumor Immunity

AU - Byun, Jun Kyu

AU - Park, Mihyang

AU - Lee, Seunghyeong

AU - Yun, Jae Won

AU - Lee, Jaebon

AU - Kim, Jae Sun

AU - Cho, Sung Jin

AU - Jeon, Hui Jeon

AU - Lee, In Kyu

AU - Choi, Yeon Kyung

AU - Park, Keun Gyu

PY - 2020/11/19

Y1 - 2020/11/19

N2 - Byun et al. demonstrated that upregulation of PD-L1 expression in cancer cells in a glutamine-poor tumor microenvironment dampens the antitumor properties of T cells, even though Fas-induced apoptosis signaling is upregulated. However, combined treatment with an inhibitor of glutamine utilization and anti-PD-L1 antibody significantly increased T-cell-mediated cancer cell death.

AB - Byun et al. demonstrated that upregulation of PD-L1 expression in cancer cells in a glutamine-poor tumor microenvironment dampens the antitumor properties of T cells, even though Fas-induced apoptosis signaling is upregulated. However, combined treatment with an inhibitor of glutamine utilization and anti-PD-L1 antibody significantly increased T-cell-mediated cancer cell death.

KW - PD-L1

KW - SERCA

KW - antitumor immunity

KW - glutamine

UR - http://www.scopus.com/inward/record.url?scp=85096196797&partnerID=8YFLogxK

U2 - 10.1016/j.molcel.2020.10.015

DO - 10.1016/j.molcel.2020.10.015

M3 - Article

C2 - 33159855

AN - SCOPUS:85096196797

SN - 1097-2765

VL - 80

SP - 592-606.e8

JO - Molecular Cell

JF - Molecular Cell

IS - 4

ER -

Inhibition of Glutamine Utilization Synergizes with Immune Checkpoint Inhibitor to Promote Antitumor Immunity

Abstract

Keywords

UN SDGs

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