Inhibition of Glutamine Utilization Synergizes with Immune Checkpoint Inhibitor to Promote Antitumor Immunity

Jun Kyu Byun; Mihyang Park; Seunghyeong Lee; Jae Won Yun; Jaebon Lee; Jae Sun Kim; Sung Jin Cho; Hui Jeon Jeon; In Kyu Lee; Yeon Kyung Choi; Keun Gyu Park

doi:10.1016/j.molcel.2020.10.015

Inhibition of Glutamine Utilization Synergizes with Immune Checkpoint Inhibitor to Promote Antitumor Immunity

Jun Kyu Byun
, Mihyang Park
, Seunghyeong Lee
, Jae Won Yun
, Jaebon Lee
, Jae Sun Kim
, Sung Jin Cho
, Hui Jeon Jeon
, In Kyu Lee
, Yeon Kyung Choi
, Keun Gyu Park

Kyungpook National University
Veterans Health Service Medical Center
Sungkyunkwan University
Daegu-Gyeongbuk Medical Innovation Foundation

Research output: Contribution to journal › Article › peer-review

187 Scopus citations

Abstract

Byun et al. demonstrated that upregulation of PD-L1 expression in cancer cells in a glutamine-poor tumor microenvironment dampens the antitumor properties of T cells, even though Fas-induced apoptosis signaling is upregulated. However, combined treatment with an inhibitor of glutamine utilization and anti-PD-L1 antibody significantly increased T-cell-mediated cancer cell death.

Original language	English
Pages (from-to)	592-606.e8
Journal	Molecular Cell
Volume	80
Issue number	4
DOIs	https://doi.org/10.1016/j.molcel.2020.10.015
State	Published - 19 Nov 2020

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

PD-L1
SERCA
antitumor immunity
glutamine

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10.1016/j.molcel.2020.10.015

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title = "Inhibition of Glutamine Utilization Synergizes with Immune Checkpoint Inhibitor to Promote Antitumor Immunity",

abstract = "Byun et al. demonstrated that upregulation of PD-L1 expression in cancer cells in a glutamine-poor tumor microenvironment dampens the antitumor properties of T cells, even though Fas-induced apoptosis signaling is upregulated. However, combined treatment with an inhibitor of glutamine utilization and anti-PD-L1 antibody significantly increased T-cell-mediated cancer cell death.",

keywords = "PD-L1, SERCA, antitumor immunity, glutamine",

author = "Byun, \{Jun Kyu\} and Mihyang Park and Seunghyeong Lee and Yun, \{Jae Won\} and Jaebon Lee and Kim, \{Jae Sun\} and Cho, \{Sung Jin\} and Jeon, \{Hui Jeon\} and Lee, \{In Kyu\} and Choi, \{Yeon Kyung\} and Park, \{Keun Gyu\}",

note = "Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",

year = "2020",

month = nov,

day = "19",

doi = "10.1016/j.molcel.2020.10.015",

language = "English",

volume = "80",

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journal = "Molecular Cell",

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T1 - Inhibition of Glutamine Utilization Synergizes with Immune Checkpoint Inhibitor to Promote Antitumor Immunity

AU - Byun, Jun Kyu

AU - Park, Mihyang

AU - Lee, Seunghyeong

AU - Yun, Jae Won

AU - Lee, Jaebon

AU - Kim, Jae Sun

AU - Cho, Sung Jin

AU - Jeon, Hui Jeon

AU - Lee, In Kyu

AU - Choi, Yeon Kyung

AU - Park, Keun Gyu

PY - 2020/11/19

Y1 - 2020/11/19

N2 - Byun et al. demonstrated that upregulation of PD-L1 expression in cancer cells in a glutamine-poor tumor microenvironment dampens the antitumor properties of T cells, even though Fas-induced apoptosis signaling is upregulated. However, combined treatment with an inhibitor of glutamine utilization and anti-PD-L1 antibody significantly increased T-cell-mediated cancer cell death.

AB - Byun et al. demonstrated that upregulation of PD-L1 expression in cancer cells in a glutamine-poor tumor microenvironment dampens the antitumor properties of T cells, even though Fas-induced apoptosis signaling is upregulated. However, combined treatment with an inhibitor of glutamine utilization and anti-PD-L1 antibody significantly increased T-cell-mediated cancer cell death.

KW - PD-L1

KW - SERCA

KW - antitumor immunity

KW - glutamine

UR - https://www.scopus.com/pages/publications/85096196797

U2 - 10.1016/j.molcel.2020.10.015

DO - 10.1016/j.molcel.2020.10.015

M3 - Article

C2 - 33159855

AN - SCOPUS:85096196797

SN - 1097-2765

VL - 80

SP - 592-606.e8

JO - Molecular Cell

JF - Molecular Cell

IS - 4

ER -

Inhibition of Glutamine Utilization Synergizes with Immune Checkpoint Inhibitor to Promote Antitumor Immunity

Abstract

UN SDGs

Keywords

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