Inhibition of migration and invasion by tet-1 overexpression in human lung carcinoma H460 cells

Si Jun Park; Bo Ram Lee; Hyeng Soo Kim; Young Rae Ji; Yong Hun Sung; Kwang Shikchoi; Hum Dai Park; Sung Hyun Kim; Myoung Ok Kim; Zae Young Ryoo

doi:10.3727/096504015X14496932933539

Inhibition of migration and invasion by tet-1 overexpression in human lung carcinoma H460 cells

Si Jun Park
, Bo Ram Lee
, Hyeng Soo Kim
, Young Rae Ji
, Yong Hun Sung
, Kwang Shikchoi
, Hum Dai Park
, Sung Hyun Kim
, Myoung Ok Kim
, Zae Young Ryoo

Kyungpook National University
Daegu University

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

In the present study, we found that lung cancer cell line (H460 cells) expressing Tet1 showed higher levels of adhesion, and Tet1 inhibited H460 cell proliferation. In addition, these cells showed a significantly reduced ability of collagen degradation and Smad2/3 phosphorylation compared to controls. Furthermore, vimentin was found to be highly expressed in larger metastatic cancer area. Tet1 overexpression was reduced in the epithelial marker E-cadherin. Moreover, Tet1 repressed cancer cell metastasis in nude mice. Collectively, these findings suggest that Tet1 expression plays a critical role in metastasis of lung cancer cells by suppression of invasion and epithelial-mesenchymal transition (EMT).

Original language	English
Pages (from-to)	89-98
Number of pages	10
Journal	Oncology Research
Volume	23
Issue number	3
DOIs	https://doi.org/10.3727/096504015X14496932933539
State	Published - 2016

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Demethylation
Epithelial-mesenchymal transition (EMT)
Lung cancer
Metastasis
Tet1

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10.3727/096504015X14496932933539

Cite this

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title = "Inhibition of migration and invasion by tet-1 overexpression in human lung carcinoma H460 cells",

abstract = "In the present study, we found that lung cancer cell line (H460 cells) expressing Tet1 showed higher levels of adhesion, and Tet1 inhibited H460 cell proliferation. In addition, these cells showed a significantly reduced ability of collagen degradation and Smad2/3 phosphorylation compared to controls. Furthermore, vimentin was found to be highly expressed in larger metastatic cancer area. Tet1 overexpression was reduced in the epithelial marker E-cadherin. Moreover, Tet1 repressed cancer cell metastasis in nude mice. Collectively, these findings suggest that Tet1 expression plays a critical role in metastasis of lung cancer cells by suppression of invasion and epithelial-mesenchymal transition (EMT).",

keywords = "Demethylation, Epithelial-mesenchymal transition (EMT), Lung cancer, Metastasis, Tet1",

author = "Park, \{Si Jun\} and Lee, \{Bo Ram\} and Kim, \{Hyeng Soo\} and Ji, \{Young Rae\} and Sung, \{Yong Hun\} and Kwang Shikchoi and Park, \{Hum Dai\} and Kim, \{Sung Hyun\} and Kim, \{Myoung Ok\} and Ryoo, \{Zae Young\}",

note = "Publisher Copyright: Copyright {\textcopyright} 2016 Cognizant, LLC.",

year = "2016",

doi = "10.3727/096504015X14496932933539",

language = "English",

volume = "23",

pages = "89--98",

journal = "Oncology Research",

issn = "0965-0407",

publisher = "Tech Science Press",

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}

TY - JOUR

T1 - Inhibition of migration and invasion by tet-1 overexpression in human lung carcinoma H460 cells

AU - Park, Si Jun

AU - Lee, Bo Ram

AU - Kim, Hyeng Soo

AU - Ji, Young Rae

AU - Sung, Yong Hun

AU - Shikchoi, Kwang

AU - Park, Hum Dai

AU - Kim, Sung Hyun

AU - Kim, Myoung Ok

AU - Ryoo, Zae Young

PY - 2016

Y1 - 2016

N2 - In the present study, we found that lung cancer cell line (H460 cells) expressing Tet1 showed higher levels of adhesion, and Tet1 inhibited H460 cell proliferation. In addition, these cells showed a significantly reduced ability of collagen degradation and Smad2/3 phosphorylation compared to controls. Furthermore, vimentin was found to be highly expressed in larger metastatic cancer area. Tet1 overexpression was reduced in the epithelial marker E-cadherin. Moreover, Tet1 repressed cancer cell metastasis in nude mice. Collectively, these findings suggest that Tet1 expression plays a critical role in metastasis of lung cancer cells by suppression of invasion and epithelial-mesenchymal transition (EMT).

AB - In the present study, we found that lung cancer cell line (H460 cells) expressing Tet1 showed higher levels of adhesion, and Tet1 inhibited H460 cell proliferation. In addition, these cells showed a significantly reduced ability of collagen degradation and Smad2/3 phosphorylation compared to controls. Furthermore, vimentin was found to be highly expressed in larger metastatic cancer area. Tet1 overexpression was reduced in the epithelial marker E-cadherin. Moreover, Tet1 repressed cancer cell metastasis in nude mice. Collectively, these findings suggest that Tet1 expression plays a critical role in metastasis of lung cancer cells by suppression of invasion and epithelial-mesenchymal transition (EMT).

KW - Demethylation

KW - Epithelial-mesenchymal transition (EMT)

KW - Lung cancer

KW - Metastasis

KW - Tet1

UR - https://www.scopus.com/pages/publications/84959329059

U2 - 10.3727/096504015X14496932933539

DO - 10.3727/096504015X14496932933539

M3 - Article

C2 - 26931431

AN - SCOPUS:84959329059

SN - 0965-0407

VL - 23

SP - 89

EP - 98

JO - Oncology Research

JF - Oncology Research

IS - 3

ER -

Inhibition of migration and invasion by tet-1 overexpression in human lung carcinoma H460 cells

Abstract

UN SDGs

Keywords

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