TY - JOUR
T1 - Inhibition on LDL-oxidation by phenolic compounds from the fruit body of phellinus linteus
AU - Lyu, Ha Na
AU - Lee, Dae Young
AU - Lee, Min Kyung
AU - Cho, Moon Hee
AU - Jeong, Tae Sook
AU - Kim, In Ho
AU - Lee, Chang Ho
AU - Baeki, Nam In
PY - 2009
Y1 - 2009
N2 - The fruit body of Pheiinus linteus was extracted with 80% aqueous MeOH, and the concentrated extract was successively partitioned using EtOAc, n-BuOH and H20. From the EtOAc and nBuOH fractions, three phenolic compounds were isolated through repeated silica gel and ODS column chromatography. The chemical structures of these compounds were determined as 2-(3',4'- dihydroxyphenyl)-1,3- benzodioxole-5-aldehyde (1), 4-(3,4-dihydroxyphenyl)-3-buten-2-one (2), and protocatechuic acid methyl ester (3) by spectroscopic data including NMR, MS and IR. Compounds 1̃3 exhibited low density lipoprotein (LDL) antioxidant activity with IC50 values of 1.7, 0.7, and 2.4 μM, respectively.
AB - The fruit body of Pheiinus linteus was extracted with 80% aqueous MeOH, and the concentrated extract was successively partitioned using EtOAc, n-BuOH and H20. From the EtOAc and nBuOH fractions, three phenolic compounds were isolated through repeated silica gel and ODS column chromatography. The chemical structures of these compounds were determined as 2-(3',4'- dihydroxyphenyl)-1,3- benzodioxole-5-aldehyde (1), 4-(3,4-dihydroxyphenyl)-3-buten-2-one (2), and protocatechuic acid methyl ester (3) by spectroscopic data including NMR, MS and IR. Compounds 1̃3 exhibited low density lipoprotein (LDL) antioxidant activity with IC50 values of 1.7, 0.7, and 2.4 μM, respectively.
KW - 2-(34-dihydroxyphenyl)-1
KW - 3-benzodioxole-5-aldehyde
KW - 4-(3,4-dihydroxphenyl)- 3-buten-2-one
KW - LDL-oxi - dation Phellinus linteus
KW - Phenolic compound
KW - Protocatechuic acid methyl este
UR - https://www.scopus.com/pages/publications/77951545026
U2 - 10.3839/jabc.2009.025
DO - 10.3839/jabc.2009.025
M3 - Article
AN - SCOPUS:77951545026
SN - 1976-0442
VL - 52
SP - 147
EP - 150
JO - Journal of Applied Biological Chemistry
JF - Journal of Applied Biological Chemistry
IS - 3
ER -