Inhibitory activities of ethanol extracts from Saururus chinensis L. against stress-induced hemorrhagic gastritis

So Young Park, Young Je Cho

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

In this study, gastritis inhibitory substance was ethanol-extracted from Saururus chinensis in order to examine the effect as a part of natural bioactive substance research. In an oral administration experiment, S. chinensis was administered at doses of 0.25 g/kg B.W. to 2 g/kg B.W., resulting in stabilization at 1.5 g/kg B.W. and an LD50 of 1.81 g/kg B.W. In a chronic toxicity experiment, 0.5 g/kg B.W. of S. chinensis was administered for 13 weeks, but toxicity was not observed. S. chinensis ethanol-extracts were administered at a concentration of 250 or 500 mg/kg B.W. before induction of gastritis. Gastrorrhagia, stomach edema, cytokine production, and cell damage were reduced in a concentration-dependent manner. Therefore, S. chinensis ethanol extracts inhibit cell damage by stress-induced hemorrhagic gastritis in a concentration-dependent manner via inhibition of cytokine expression.

Original languageEnglish
Pages (from-to)800-808
Number of pages9
JournalJournal of the Korean Society of Food Science and Nutrition
Volume44
Issue number6
DOIs
StatePublished - 30 Jun 2015

Keywords

  • Extracts
  • Inhibitory activity
  • Saururus chinensis
  • Stress-induced hemorrhagic gastritis

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