Inhibitory effect of ginsenosides from ginseng leaves and flowers on the LPS-stimulated IL-12 production in bone marrow-derived dendritic cells

Nguyen Huu Tung; Seok Bean Song; Gyu Yong Song; Jeong Ah Kim; Jung Eun Koo; Hee Kyoung Kang; Young Sang Koh; Young Ho Kim

doi:10.1007/s10068-010-0159-y

Inhibitory effect of ginsenosides from ginseng leaves and flowers on the LPS-stimulated IL-12 production in bone marrow-derived dendritic cells

Nguyen Huu Tung, Seok Bean Song, Gyu Yong Song, Jeong Ah Kim, Jung Eun Koo, Hee Kyoung Kang, Young Sang Koh, Young Ho Kim

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Ginseng leaves and flowers have been known to be rich in various ginsenosides. The aim of present study is to screen the effect of 34 ginsenosides from ginseng leaves and flowers on interlukin (IL)-12 production in bone marrow-derived dendritic cells induced by lipopoly-saccharide (LPS). Noticeably, floralginsenoside Kc (5), floralginsenoside J (26), and ginsenoside I (33) exhibited particularly inhibitory effect on LPS-induced IL-12 production with IC₅₀ values of 16.3, 25.8, and 6.7 μM, respectively. In addition, floralginsenoside Kc (5) suppressed significantly LPS-stimulated IL-6 and tumor necrosis factor-α (TNF-α) production. These results warrant further studies concerning potential of saponin extracts of Panax ginseng leaves and flowers for medicinal foods.

Original language	English
Pages (from-to)	1119-1122
Number of pages	4
Journal	Food Science and Biotechnology
Volume	19
Issue number	4
DOIs	https://doi.org/10.1007/s10068-010-0159-y
State	Published - Aug 2010

Keywords

Bone marrow-derived dendritic cell
Ginsenoside
Interleukin-12
Panax ginseng

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title = "Inhibitory effect of ginsenosides from ginseng leaves and flowers on the LPS-stimulated IL-12 production in bone marrow-derived dendritic cells",

abstract = "Ginseng leaves and flowers have been known to be rich in various ginsenosides. The aim of present study is to screen the effect of 34 ginsenosides from ginseng leaves and flowers on interlukin (IL)-12 production in bone marrow-derived dendritic cells induced by lipopoly-saccharide (LPS). Noticeably, floralginsenoside Kc (5), floralginsenoside J (26), and ginsenoside I (33) exhibited particularly inhibitory effect on LPS-induced IL-12 production with IC50 values of 16.3, 25.8, and 6.7 μM, respectively. In addition, floralginsenoside Kc (5) suppressed significantly LPS-stimulated IL-6 and tumor necrosis factor-α (TNF-α) production. These results warrant further studies concerning potential of saponin extracts of Panax ginseng leaves and flowers for medicinal foods.",

keywords = "Bone marrow-derived dendritic cell, Ginsenoside, Interleukin-12, Panax ginseng",

author = "Tung, {Nguyen Huu} and Song, {Seok Bean} and Song, {Gyu Yong} and Kim, {Jeong Ah} and Koo, {Jung Eun} and Kang, {Hee Kyoung} and Koh, {Young Sang} and Kim, {Young Ho}",

year = "2010",

month = aug,

doi = "10.1007/s10068-010-0159-y",

language = "English",

volume = "19",

pages = "1119--1122",

journal = "Food Science and Biotechnology",

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TY - JOUR

T1 - Inhibitory effect of ginsenosides from ginseng leaves and flowers on the LPS-stimulated IL-12 production in bone marrow-derived dendritic cells

AU - Tung, Nguyen Huu

AU - Song, Seok Bean

AU - Song, Gyu Yong

AU - Kim, Jeong Ah

AU - Koo, Jung Eun

AU - Kang, Hee Kyoung

AU - Koh, Young Sang

AU - Kim, Young Ho

PY - 2010/8

Y1 - 2010/8

N2 - Ginseng leaves and flowers have been known to be rich in various ginsenosides. The aim of present study is to screen the effect of 34 ginsenosides from ginseng leaves and flowers on interlukin (IL)-12 production in bone marrow-derived dendritic cells induced by lipopoly-saccharide (LPS). Noticeably, floralginsenoside Kc (5), floralginsenoside J (26), and ginsenoside I (33) exhibited particularly inhibitory effect on LPS-induced IL-12 production with IC50 values of 16.3, 25.8, and 6.7 μM, respectively. In addition, floralginsenoside Kc (5) suppressed significantly LPS-stimulated IL-6 and tumor necrosis factor-α (TNF-α) production. These results warrant further studies concerning potential of saponin extracts of Panax ginseng leaves and flowers for medicinal foods.

AB - Ginseng leaves and flowers have been known to be rich in various ginsenosides. The aim of present study is to screen the effect of 34 ginsenosides from ginseng leaves and flowers on interlukin (IL)-12 production in bone marrow-derived dendritic cells induced by lipopoly-saccharide (LPS). Noticeably, floralginsenoside Kc (5), floralginsenoside J (26), and ginsenoside I (33) exhibited particularly inhibitory effect on LPS-induced IL-12 production with IC50 values of 16.3, 25.8, and 6.7 μM, respectively. In addition, floralginsenoside Kc (5) suppressed significantly LPS-stimulated IL-6 and tumor necrosis factor-α (TNF-α) production. These results warrant further studies concerning potential of saponin extracts of Panax ginseng leaves and flowers for medicinal foods.

KW - Bone marrow-derived dendritic cell

KW - Ginsenoside

KW - Interleukin-12

KW - Panax ginseng

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U2 - 10.1007/s10068-010-0159-y

DO - 10.1007/s10068-010-0159-y

M3 - Article

AN - SCOPUS:79957628176

SN - 1226-7708

VL - 19

SP - 1119

EP - 1122

JO - Food Science and Biotechnology

JF - Food Science and Biotechnology

IS - 4

ER -

Inhibitory effect of ginsenosides from ginseng leaves and flowers on the LPS-stimulated IL-12 production in bone marrow-derived dendritic cells

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Keywords

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