Inhibitory effect of pelargonidin on secretory group IIA phospholipase A2

In Chul Lee; Jong Sup Bae

doi:10.1177/1934578x1801300811

Inhibitory effect of pelargonidin on secretory group IIA phospholipase A2

In Chul Lee, Jong Sup Bae

Seowon University

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

The expression of secretory group IIA phospholipase A2 (sPLA2-IIA) has been shown to be elevated in various inflammatory diseases, and lipopolysaccharide (LPS) up-regulates the expression of sPLA2-IIA in human umbilical vein endothelial cells (HUVECs). Pelargonidin (PEL) is a well-known red pigment found in plants, and has been reported as having important biological activities that are potentially beneficial for human health. Here, PEL was examined for its effects on the expression and activity of sPLA2-IIA in HUVECs and mouse. Post treatment of cells or mouse with PEL inhibited LPS-induced expression and activity of sPLA2-IIA. Therefore, these results suggest that PEL inhibited LPS mediated expression of sPLA2-IIA.

Original language	English
Pages (from-to)	963-966
Number of pages	4
Journal	Natural Product Communications
Volume	13
Issue number	8
DOIs	https://doi.org/10.1177/1934578x1801300811
State	Published - Aug 2018

Keywords

HUVEC
Inflammation
Pelargonidin
SPLA2-IIA

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1177/1934578x1801300811

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title = "Inhibitory effect of pelargonidin on secretory group IIA phospholipase A2",

abstract = "The expression of secretory group IIA phospholipase A2 (sPLA2-IIA) has been shown to be elevated in various inflammatory diseases, and lipopolysaccharide (LPS) up-regulates the expression of sPLA2-IIA in human umbilical vein endothelial cells (HUVECs). Pelargonidin (PEL) is a well-known red pigment found in plants, and has been reported as having important biological activities that are potentially beneficial for human health. Here, PEL was examined for its effects on the expression and activity of sPLA2-IIA in HUVECs and mouse. Post treatment of cells or mouse with PEL inhibited LPS-induced expression and activity of sPLA2-IIA. Therefore, these results suggest that PEL inhibited LPS mediated expression of sPLA2-IIA.",

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author = "Lee, {In Chul} and Bae, {Jong Sup}",

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doi = "10.1177/1934578x1801300811",

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T1 - Inhibitory effect of pelargonidin on secretory group IIA phospholipase A2

AU - Lee, In Chul

AU - Bae, Jong Sup

PY - 2018/8

Y1 - 2018/8

N2 - The expression of secretory group IIA phospholipase A2 (sPLA2-IIA) has been shown to be elevated in various inflammatory diseases, and lipopolysaccharide (LPS) up-regulates the expression of sPLA2-IIA in human umbilical vein endothelial cells (HUVECs). Pelargonidin (PEL) is a well-known red pigment found in plants, and has been reported as having important biological activities that are potentially beneficial for human health. Here, PEL was examined for its effects on the expression and activity of sPLA2-IIA in HUVECs and mouse. Post treatment of cells or mouse with PEL inhibited LPS-induced expression and activity of sPLA2-IIA. Therefore, these results suggest that PEL inhibited LPS mediated expression of sPLA2-IIA.

AB - The expression of secretory group IIA phospholipase A2 (sPLA2-IIA) has been shown to be elevated in various inflammatory diseases, and lipopolysaccharide (LPS) up-regulates the expression of sPLA2-IIA in human umbilical vein endothelial cells (HUVECs). Pelargonidin (PEL) is a well-known red pigment found in plants, and has been reported as having important biological activities that are potentially beneficial for human health. Here, PEL was examined for its effects on the expression and activity of sPLA2-IIA in HUVECs and mouse. Post treatment of cells or mouse with PEL inhibited LPS-induced expression and activity of sPLA2-IIA. Therefore, these results suggest that PEL inhibited LPS mediated expression of sPLA2-IIA.

KW - HUVEC

KW - Inflammation

KW - Pelargonidin

KW - SPLA2-IIA

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DO - 10.1177/1934578x1801300811

M3 - Article

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SN - 1934-578X

VL - 13

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EP - 966

JO - Natural Product Communications

JF - Natural Product Communications

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ER -

Inhibitory effect of pelargonidin on secretory group IIA phospholipase A2

Abstract

Keywords

UN SDGs

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