Inhibitory effect of polyozellin on secretory group IIA phospholipase A2

Sae Kwang Ku; Eun Ju Yang; Hyejin Kang; Byeongjin Jung; Jong Sup Bae

doi:10.1007/s12272-015-0694-4

Inhibitory effect of polyozellin on secretory group IIA phospholipase A2

Sae Kwang Ku, Eun Ju Yang, Hyejin Kang, Byeongjin Jung, Jong Sup Bae

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

The expression of secretory group IIA phospholipase A2 (sPLA2-IIA) is enhanced by development of inflammatory disorders. In this study, sPLA2-IIA expression was induced in the lipopolysaccharide (LPS)-stimulated human umbilical vein endothelial cells and mice to evaluate the effect of polyozellin. Polyozellin, a major constituent of a Korea edible mushroom Polyozellus multiplex, has been known to exhibit the biological activities such as anti-oxidative and anti-inflammatory effects. Polyozellin remarkably suppressed the LPS-mediated protein expression and activity of sPLA2-IIA via inhibition of phosphorylation of cytosolic phospholipase A2 and extracellular signal-regulated kinase 1/2. These results demonstrated that polyozellin might play an important role in the modulation of sPLA2-IIA expression and activity in response to the inflammatory diseases.

Original language	English
Pages (from-to)	271-278
Number of pages	8
Journal	Archives of Pharmacal Research
Volume	39
Issue number	2
DOIs	https://doi.org/10.1007/s12272-015-0694-4
State	Published - 1 Feb 2016

Keywords

HUVECs
Inflammation
Polyozellin
sPLA2-IIA

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s12272-015-0694-4

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title = "Inhibitory effect of polyozellin on secretory group IIA phospholipase A2",

abstract = "The expression of secretory group IIA phospholipase A2 (sPLA2-IIA) is enhanced by development of inflammatory disorders. In this study, sPLA2-IIA expression was induced in the lipopolysaccharide (LPS)-stimulated human umbilical vein endothelial cells and mice to evaluate the effect of polyozellin. Polyozellin, a major constituent of a Korea edible mushroom Polyozellus multiplex, has been known to exhibit the biological activities such as anti-oxidative and anti-inflammatory effects. Polyozellin remarkably suppressed the LPS-mediated protein expression and activity of sPLA2-IIA via inhibition of phosphorylation of cytosolic phospholipase A2 and extracellular signal-regulated kinase 1/2. These results demonstrated that polyozellin might play an important role in the modulation of sPLA2-IIA expression and activity in response to the inflammatory diseases.",

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author = "Ku, {Sae Kwang} and Yang, {Eun Ju} and Hyejin Kang and Byeongjin Jung and Bae, {Jong Sup}",

note = "Publisher Copyright: {\textcopyright} 2015 The Pharmaceutical Society of Korea.",

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doi = "10.1007/s12272-015-0694-4",

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T1 - Inhibitory effect of polyozellin on secretory group IIA phospholipase A2

AU - Ku, Sae Kwang

AU - Yang, Eun Ju

AU - Kang, Hyejin

AU - Jung, Byeongjin

AU - Bae, Jong Sup

PY - 2016/2/1

Y1 - 2016/2/1

N2 - The expression of secretory group IIA phospholipase A2 (sPLA2-IIA) is enhanced by development of inflammatory disorders. In this study, sPLA2-IIA expression was induced in the lipopolysaccharide (LPS)-stimulated human umbilical vein endothelial cells and mice to evaluate the effect of polyozellin. Polyozellin, a major constituent of a Korea edible mushroom Polyozellus multiplex, has been known to exhibit the biological activities such as anti-oxidative and anti-inflammatory effects. Polyozellin remarkably suppressed the LPS-mediated protein expression and activity of sPLA2-IIA via inhibition of phosphorylation of cytosolic phospholipase A2 and extracellular signal-regulated kinase 1/2. These results demonstrated that polyozellin might play an important role in the modulation of sPLA2-IIA expression and activity in response to the inflammatory diseases.

AB - The expression of secretory group IIA phospholipase A2 (sPLA2-IIA) is enhanced by development of inflammatory disorders. In this study, sPLA2-IIA expression was induced in the lipopolysaccharide (LPS)-stimulated human umbilical vein endothelial cells and mice to evaluate the effect of polyozellin. Polyozellin, a major constituent of a Korea edible mushroom Polyozellus multiplex, has been known to exhibit the biological activities such as anti-oxidative and anti-inflammatory effects. Polyozellin remarkably suppressed the LPS-mediated protein expression and activity of sPLA2-IIA via inhibition of phosphorylation of cytosolic phospholipase A2 and extracellular signal-regulated kinase 1/2. These results demonstrated that polyozellin might play an important role in the modulation of sPLA2-IIA expression and activity in response to the inflammatory diseases.

KW - HUVECs

KW - Inflammation

KW - Polyozellin

KW - sPLA2-IIA

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SN - 0253-6269

VL - 39

SP - 271

EP - 278

JO - Archives of Pharmacal Research

JF - Archives of Pharmacal Research

IS - 2

ER -

Inhibitory effect of polyozellin on secretory group IIA phospholipase A2

Abstract

Keywords

UN SDGs

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