Abstract
We studied the inhibitory effect of the aqueous extract of Salvia plebeia (SPAE) on immediate hypersensitivity reactions. SPAE inhibited immediate hypersensitivity reaction induced by compound 48/80 in mice. When SPAE was employed in an immediate hypersensitivity reaction test, the plasma histamine levels were reduced in a dose-dependent manner. SPAE also inhibited the histamine release from rat peritoneal mast cells (RPMC) by compound 48/80. The level of cAMP in RPMC, when SPAE was added, significantly increased compared with that of a normal control. These results indicate that SPAE may be beneficial in the treatment of immediate hypersensitivity reactions.
Original language | English |
---|---|
Pages (from-to) | 297-301 |
Number of pages | 5 |
Journal | Korean Journal of Pharmacognosy |
Volume | 32 |
Issue number | 4 |
State | Published - 2001 |
Keywords
- cAMP
- Compound 48/80
- Histamine
- Immediate hypersensitivity reaction
- Mast cells
- Salvia plebeia