Inhibitory effect of Salvia plebeia on compound 48/80-induced immediate hypersensitivity reaction

Yong Gil Choi, Sang Hyun Kim, Jong Pil Lim, Dae Keun Kim, Dong Ok Eom, Kyeong Bo Lee, Sang Yong Kim, Tae Yong Shin

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

We studied the inhibitory effect of the aqueous extract of Salvia plebeia (SPAE) on immediate hypersensitivity reactions. SPAE inhibited immediate hypersensitivity reaction induced by compound 48/80 in mice. When SPAE was employed in an immediate hypersensitivity reaction test, the plasma histamine levels were reduced in a dose-dependent manner. SPAE also inhibited the histamine release from rat peritoneal mast cells (RPMC) by compound 48/80. The level of cAMP in RPMC, when SPAE was added, significantly increased compared with that of a normal control. These results indicate that SPAE may be beneficial in the treatment of immediate hypersensitivity reactions.

Original languageEnglish
Pages (from-to)297-301
Number of pages5
JournalKorean Journal of Pharmacognosy
Volume32
Issue number4
StatePublished - 2001

Keywords

  • cAMP
  • Compound 48/80
  • Histamine
  • Immediate hypersensitivity reaction
  • Mast cells
  • Salvia plebeia

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