Inhibitory effect of Salvia plebeia on compound 48/80-induced immediate hypersensitivity reaction

Yong Gil Choi; Sang Hyun Kim; Jong Pil Lim; Dae Keun Kim; Dong Ok Eom; Kyeong Bo Lee; Sang Yong Kim; Tae Yong Shin

Inhibitory effect of Salvia plebeia on compound 48/80-induced immediate hypersensitivity reaction

Yong Gil Choi
, Sang Hyun Kim
, Jong Pil Lim
, Dae Keun Kim
, Dong Ok Eom
, Kyeong Bo Lee
, Sang Yong Kim
, Tae Yong Shin

Department of Medicine

Woosuk University

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

We studied the inhibitory effect of the aqueous extract of Salvia plebeia (SPAE) on immediate hypersensitivity reactions. SPAE inhibited immediate hypersensitivity reaction induced by compound 48/80 in mice. When SPAE was employed in an immediate hypersensitivity reaction test, the plasma histamine levels were reduced in a dose-dependent manner. SPAE also inhibited the histamine release from rat peritoneal mast cells (RPMC) by compound 48/80. The level of cAMP in RPMC, when SPAE was added, significantly increased compared with that of a normal control. These results indicate that SPAE may be beneficial in the treatment of immediate hypersensitivity reactions.

Original language	English
Pages (from-to)	297-301
Number of pages	5
Journal	Korean Journal of Pharmacognosy
Volume	32
Issue number	4
State	Published - 2001

Keywords

cAMP
Compound 48/80
Histamine
Immediate hypersensitivity reaction
Mast cells
Salvia plebeia

Cite this

@article{8198bf98361e420d9eb9222f32360c2c,

title = "Inhibitory effect of Salvia plebeia on compound 48/80-induced immediate hypersensitivity reaction",

abstract = "We studied the inhibitory effect of the aqueous extract of Salvia plebeia (SPAE) on immediate hypersensitivity reactions. SPAE inhibited immediate hypersensitivity reaction induced by compound 48/80 in mice. When SPAE was employed in an immediate hypersensitivity reaction test, the plasma histamine levels were reduced in a dose-dependent manner. SPAE also inhibited the histamine release from rat peritoneal mast cells (RPMC) by compound 48/80. The level of cAMP in RPMC, when SPAE was added, significantly increased compared with that of a normal control. These results indicate that SPAE may be beneficial in the treatment of immediate hypersensitivity reactions.",

keywords = "cAMP, Compound 48/80, Histamine, Immediate hypersensitivity reaction, Mast cells, Salvia plebeia",

author = "Choi, \{Yong Gil\} and Kim, \{Sang Hyun\} and Lim, \{Jong Pil\} and Kim, \{Dae Keun\} and Eom, \{Dong Ok\} and Lee, \{Kyeong Bo\} and Kim, \{Sang Yong\} and Shin, \{Tae Yong\}",

year = "2001",

language = "English",

volume = "32",

pages = "297--301",

journal = "Korean Journal of Pharmacognosy",

issn = "0253-3073",

publisher = "Korean Society of Pharmacognosy",

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}

TY - JOUR

T1 - Inhibitory effect of Salvia plebeia on compound 48/80-induced immediate hypersensitivity reaction

AU - Choi, Yong Gil

AU - Kim, Sang Hyun

AU - Lim, Jong Pil

AU - Kim, Dae Keun

AU - Eom, Dong Ok

AU - Lee, Kyeong Bo

AU - Kim, Sang Yong

AU - Shin, Tae Yong

PY - 2001

Y1 - 2001

N2 - We studied the inhibitory effect of the aqueous extract of Salvia plebeia (SPAE) on immediate hypersensitivity reactions. SPAE inhibited immediate hypersensitivity reaction induced by compound 48/80 in mice. When SPAE was employed in an immediate hypersensitivity reaction test, the plasma histamine levels were reduced in a dose-dependent manner. SPAE also inhibited the histamine release from rat peritoneal mast cells (RPMC) by compound 48/80. The level of cAMP in RPMC, when SPAE was added, significantly increased compared with that of a normal control. These results indicate that SPAE may be beneficial in the treatment of immediate hypersensitivity reactions.

AB - We studied the inhibitory effect of the aqueous extract of Salvia plebeia (SPAE) on immediate hypersensitivity reactions. SPAE inhibited immediate hypersensitivity reaction induced by compound 48/80 in mice. When SPAE was employed in an immediate hypersensitivity reaction test, the plasma histamine levels were reduced in a dose-dependent manner. SPAE also inhibited the histamine release from rat peritoneal mast cells (RPMC) by compound 48/80. The level of cAMP in RPMC, when SPAE was added, significantly increased compared with that of a normal control. These results indicate that SPAE may be beneficial in the treatment of immediate hypersensitivity reactions.

KW - cAMP

KW - Compound 48/80

KW - Histamine

KW - Immediate hypersensitivity reaction

KW - Mast cells

KW - Salvia plebeia

UR - https://www.scopus.com/pages/publications/0035713073

M3 - Article

AN - SCOPUS:0035713073

SN - 0253-3073

VL - 32

SP - 297

EP - 301

JO - Korean Journal of Pharmacognosy

JF - Korean Journal of Pharmacognosy

IS - 4

ER -

Inhibitory effect of Salvia plebeia on compound 48/80-induced immediate hypersensitivity reaction

Abstract

Keywords

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