Inhibitory effect of vicenin-2 and scolymoside on secretory group IIA phospholipase A2

In Chul Lee; Jong Sup Bae

doi:10.1080/19768354.2015.1087428

Inhibitory effect of vicenin-2 and scolymoside on secretory group IIA phospholipase A₂

In Chul Lee, Jong Sup Bae

Seowon University

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

It is well known that the expression level of secretory group IIA phospholipase A₂ (sPLA₂-IIA) is elevated in inflammatory diseases, and lipopolysaccharide (LPS) up-regulates the expression of sPLA₂-IIA in human umbilical vein endothelial cells (HUVECs). Cyclopiasubternata is a medicinal plant commonly used in traditional medicine to relieve pain in biological processes. Here, two structurally related active compounds found in C. subternata, namely vicenin-2 and scolymoside, were examined for its effects on the expression and activity of sPLA₂-IIA in HUVECs and mouse. Prior treatment of cells or mouse with vicenin-2 and scolymoside inhibited LPS-induced expression and activity of sPLA₂-IIA. And each compound suppressed the activation of cytosolic phospholipase A2 (cPLA2) and extracellular signal-regulated kinase (ERK) 1/2 by LPS. Therefore, these results suggest that vicenin-2 and scolymoside inhibited LPS-mediated expression of sPLA₂-IIA by suppression of cPLA2 and ERK 1/2.

Original language	English
Pages (from-to)	305-311
Number of pages	7
Journal	Animal Cells and Systems
Volume	19
Issue number	5
DOIs	https://doi.org/10.1080/19768354.2015.1087428
State	Published - 3 Sep 2015

Keywords

HUVEC
inflammation
scolymoside
sPLA-IIA
vicenin-2

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10.1080/19768354.2015.1087428

Cite this

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title = "Inhibitory effect of vicenin-2 and scolymoside on secretory group IIA phospholipase A2 ",

abstract = "It is well known that the expression level of secretory group IIA phospholipase A2 (sPLA2-IIA) is elevated in inflammatory diseases, and lipopolysaccharide (LPS) up-regulates the expression of sPLA2-IIA in human umbilical vein endothelial cells (HUVECs). Cyclopiasubternata is a medicinal plant commonly used in traditional medicine to relieve pain in biological processes. Here, two structurally related active compounds found in C. subternata, namely vicenin-2 and scolymoside, were examined for its effects on the expression and activity of sPLA2-IIA in HUVECs and mouse. Prior treatment of cells or mouse with vicenin-2 and scolymoside inhibited LPS-induced expression and activity of sPLA2-IIA. And each compound suppressed the activation of cytosolic phospholipase A2 (cPLA2) and extracellular signal-regulated kinase (ERK) 1/2 by LPS. Therefore, these results suggest that vicenin-2 and scolymoside inhibited LPS-mediated expression of sPLA2-IIA by suppression of cPLA2 and ERK 1/2.",

keywords = "HUVEC, inflammation, scolymoside, sPLA-IIA, vicenin-2",

author = "Lee, {In Chul} and Bae, {Jong Sup}",

note = "Publisher Copyright: {\textcopyright} 2015 Korean Society for Integrative Biology.",

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AU - Lee, In Chul

AU - Bae, Jong Sup

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N2 - It is well known that the expression level of secretory group IIA phospholipase A2 (sPLA2-IIA) is elevated in inflammatory diseases, and lipopolysaccharide (LPS) up-regulates the expression of sPLA2-IIA in human umbilical vein endothelial cells (HUVECs). Cyclopiasubternata is a medicinal plant commonly used in traditional medicine to relieve pain in biological processes. Here, two structurally related active compounds found in C. subternata, namely vicenin-2 and scolymoside, were examined for its effects on the expression and activity of sPLA2-IIA in HUVECs and mouse. Prior treatment of cells or mouse with vicenin-2 and scolymoside inhibited LPS-induced expression and activity of sPLA2-IIA. And each compound suppressed the activation of cytosolic phospholipase A2 (cPLA2) and extracellular signal-regulated kinase (ERK) 1/2 by LPS. Therefore, these results suggest that vicenin-2 and scolymoside inhibited LPS-mediated expression of sPLA2-IIA by suppression of cPLA2 and ERK 1/2.

AB - It is well known that the expression level of secretory group IIA phospholipase A2 (sPLA2-IIA) is elevated in inflammatory diseases, and lipopolysaccharide (LPS) up-regulates the expression of sPLA2-IIA in human umbilical vein endothelial cells (HUVECs). Cyclopiasubternata is a medicinal plant commonly used in traditional medicine to relieve pain in biological processes. Here, two structurally related active compounds found in C. subternata, namely vicenin-2 and scolymoside, were examined for its effects on the expression and activity of sPLA2-IIA in HUVECs and mouse. Prior treatment of cells or mouse with vicenin-2 and scolymoside inhibited LPS-induced expression and activity of sPLA2-IIA. And each compound suppressed the activation of cytosolic phospholipase A2 (cPLA2) and extracellular signal-regulated kinase (ERK) 1/2 by LPS. Therefore, these results suggest that vicenin-2 and scolymoside inhibited LPS-mediated expression of sPLA2-IIA by suppression of cPLA2 and ERK 1/2.

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