Inhibitory effect of zingerone on secretory group IIA phospholipase A2

In Chul Lee; Dae Yong Kim; Jong Sup Bae

doi:10.1177/1934578x1701200624

Inhibitory effect of zingerone on secretory group IIA phospholipase A2

In Chul Lee, Dae Yong Kim, Jong Sup Bae

Seowon University

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

The expression of secretory group IIA phospholipase A2 (sPLA2-IIA) has been shown to be elevated in various inflammatory diseases, and lipopolysaccharide (LPS) up-regulates the expression of sPLA2-IIA in human umbilical vein endothelial cells (HUVECs). Zingerone (ZGR), a phenolic alkanone isolated from ginger, has been reported to have various pharmacological activities. Here, we examined the effects of ZRG on the expression and activity of sPLA2-IIA in LPS-activated HUVECs and in mouse models of endotoxemia and sepsis. Treatment of cells or mice with ZRG inhibited LPS-induced expression and activity of sPLA2-IIA. In addition, ZRG suppressed LPS-mediated activation of cytosolic phospholipase A2 (cPLA2) and extracellular signal-regulated kinase (ERK) 1/2. These results suggest that ZRG inhibits LPS-mediated activation of sPLA2-IIA expression by suppressing cPLA2 and ERK 1/2.

Original language	English
Pages (from-to)	929-932
Number of pages	4
Journal	Natural Product Communications
Volume	12
Issue number	6
DOIs	https://doi.org/10.1177/1934578x1701200624
State	Published - Jun 2017

Keywords

HUVECs
Inflammation
SPLA2-IIA
Zingerone

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1177/1934578x1701200624

Cite this

@article{e134194870e444e299189c2db6cea189,

title = "Inhibitory effect of zingerone on secretory group IIA phospholipase A2",

abstract = "The expression of secretory group IIA phospholipase A2 (sPLA2-IIA) has been shown to be elevated in various inflammatory diseases, and lipopolysaccharide (LPS) up-regulates the expression of sPLA2-IIA in human umbilical vein endothelial cells (HUVECs). Zingerone (ZGR), a phenolic alkanone isolated from ginger, has been reported to have various pharmacological activities. Here, we examined the effects of ZRG on the expression and activity of sPLA2-IIA in LPS-activated HUVECs and in mouse models of endotoxemia and sepsis. Treatment of cells or mice with ZRG inhibited LPS-induced expression and activity of sPLA2-IIA. In addition, ZRG suppressed LPS-mediated activation of cytosolic phospholipase A2 (cPLA2) and extracellular signal-regulated kinase (ERK) 1/2. These results suggest that ZRG inhibits LPS-mediated activation of sPLA2-IIA expression by suppressing cPLA2 and ERK 1/2.",

keywords = "HUVECs, Inflammation, SPLA2-IIA, Zingerone",

author = "Lee, {In Chul} and Kim, {Dae Yong} and Bae, {Jong Sup}",

year = "2017",

month = jun,

doi = "10.1177/1934578x1701200624",

language = "English",

volume = "12",

pages = "929--932",

journal = "Natural Product Communications",

issn = "1934-578X",

publisher = "SAGE Publications Inc.",

number = "6",

}

TY - JOUR

T1 - Inhibitory effect of zingerone on secretory group IIA phospholipase A2

AU - Lee, In Chul

AU - Kim, Dae Yong

AU - Bae, Jong Sup

PY - 2017/6

Y1 - 2017/6

N2 - The expression of secretory group IIA phospholipase A2 (sPLA2-IIA) has been shown to be elevated in various inflammatory diseases, and lipopolysaccharide (LPS) up-regulates the expression of sPLA2-IIA in human umbilical vein endothelial cells (HUVECs). Zingerone (ZGR), a phenolic alkanone isolated from ginger, has been reported to have various pharmacological activities. Here, we examined the effects of ZRG on the expression and activity of sPLA2-IIA in LPS-activated HUVECs and in mouse models of endotoxemia and sepsis. Treatment of cells or mice with ZRG inhibited LPS-induced expression and activity of sPLA2-IIA. In addition, ZRG suppressed LPS-mediated activation of cytosolic phospholipase A2 (cPLA2) and extracellular signal-regulated kinase (ERK) 1/2. These results suggest that ZRG inhibits LPS-mediated activation of sPLA2-IIA expression by suppressing cPLA2 and ERK 1/2.

AB - The expression of secretory group IIA phospholipase A2 (sPLA2-IIA) has been shown to be elevated in various inflammatory diseases, and lipopolysaccharide (LPS) up-regulates the expression of sPLA2-IIA in human umbilical vein endothelial cells (HUVECs). Zingerone (ZGR), a phenolic alkanone isolated from ginger, has been reported to have various pharmacological activities. Here, we examined the effects of ZRG on the expression and activity of sPLA2-IIA in LPS-activated HUVECs and in mouse models of endotoxemia and sepsis. Treatment of cells or mice with ZRG inhibited LPS-induced expression and activity of sPLA2-IIA. In addition, ZRG suppressed LPS-mediated activation of cytosolic phospholipase A2 (cPLA2) and extracellular signal-regulated kinase (ERK) 1/2. These results suggest that ZRG inhibits LPS-mediated activation of sPLA2-IIA expression by suppressing cPLA2 and ERK 1/2.

KW - HUVECs

KW - Inflammation

KW - SPLA2-IIA

KW - Zingerone

UR - http://www.scopus.com/inward/record.url?scp=85023201192&partnerID=8YFLogxK

U2 - 10.1177/1934578x1701200624

DO - 10.1177/1934578x1701200624

M3 - Article

AN - SCOPUS:85023201192

SN - 1934-578X

VL - 12

SP - 929

EP - 932

JO - Natural Product Communications

JF - Natural Product Communications

IS - 6

ER -

Inhibitory effect of zingerone on secretory group IIA phospholipase A2

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this