Inhibitory effects of an antioxidant coating on a polylactic acid film on inflammatory cytokines from macrophage

Ga Hyun Lee; Sung June Lee; Sang Won Jeong; Hyun Chul Kim; Jin Hyun Choi; Se Geun Lee

doi:10.7317/pk.2015.39.6.934

Inhibitory effects of an antioxidant coating on a polylactic acid film on inflammatory cytokines from macrophage

Ga Hyun Lee, Sung June Lee, Sang Won Jeong, Hyun Chul Kim, Jin Hyun Choi, Se Geun Lee

Department of Biofibers and Biomaterials Science

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Polylactic acid (PLA) films have been widely used in medical devices for surgical treatments. However, their use has been associated with complications, such as inflammation around the PLA film implant area. Several antioxidant agents have been incorporated on the surface of PLA films to suppress initial excessive inflammatory reactions through the quenching of reactive oxygen species (ROS) released from macrophages. The suppression of inflammation was evaluated by measuring the levels of various pro-inflammatory cytokines produced by the macrophages. In addition, by measuring quercetin release behavior, we determined the optimum type and molecular weight of the film coating polymer for the effective suppression of inflammation. These results suggest that the incorporation and controlled release of quercetin could be a promising method to reduce inflammation induced by PLA films.

Original language	English
Pages (from-to)	934-939
Number of pages	6
Journal	Polymer (Korea)
Volume	39
Issue number	6
DOIs	https://doi.org/10.7317/pk.2015.39.6.934
State	Published - Nov 2015

Keywords

Anti-inflammatory
Antioxidant
Controlled release
Implantation
PLA film

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title = "Inhibitory effects of an antioxidant coating on a polylactic acid film on inflammatory cytokines from macrophage",

abstract = "Polylactic acid (PLA) films have been widely used in medical devices for surgical treatments. However, their use has been associated with complications, such as inflammation around the PLA film implant area. Several antioxidant agents have been incorporated on the surface of PLA films to suppress initial excessive inflammatory reactions through the quenching of reactive oxygen species (ROS) released from macrophages. The suppression of inflammation was evaluated by measuring the levels of various pro-inflammatory cytokines produced by the macrophages. In addition, by measuring quercetin release behavior, we determined the optimum type and molecular weight of the film coating polymer for the effective suppression of inflammation. These results suggest that the incorporation and controlled release of quercetin could be a promising method to reduce inflammation induced by PLA films.",

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author = "Lee, \{Ga Hyun\} and Lee, \{Sung June\} and Jeong, \{Sang Won\} and Kim, \{Hyun Chul\} and Choi, \{Jin Hyun\} and Lee, \{Se Geun\}",

year = "2015",

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language = "English",

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publisher = "Polymer Society of Korea",

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T1 - Inhibitory effects of an antioxidant coating on a polylactic acid film on inflammatory cytokines from macrophage

AU - Lee, Ga Hyun

AU - Lee, Sung June

AU - Jeong, Sang Won

AU - Kim, Hyun Chul

AU - Choi, Jin Hyun

AU - Lee, Se Geun

PY - 2015/11

Y1 - 2015/11

N2 - Polylactic acid (PLA) films have been widely used in medical devices for surgical treatments. However, their use has been associated with complications, such as inflammation around the PLA film implant area. Several antioxidant agents have been incorporated on the surface of PLA films to suppress initial excessive inflammatory reactions through the quenching of reactive oxygen species (ROS) released from macrophages. The suppression of inflammation was evaluated by measuring the levels of various pro-inflammatory cytokines produced by the macrophages. In addition, by measuring quercetin release behavior, we determined the optimum type and molecular weight of the film coating polymer for the effective suppression of inflammation. These results suggest that the incorporation and controlled release of quercetin could be a promising method to reduce inflammation induced by PLA films.

AB - Polylactic acid (PLA) films have been widely used in medical devices for surgical treatments. However, their use has been associated with complications, such as inflammation around the PLA film implant area. Several antioxidant agents have been incorporated on the surface of PLA films to suppress initial excessive inflammatory reactions through the quenching of reactive oxygen species (ROS) released from macrophages. The suppression of inflammation was evaluated by measuring the levels of various pro-inflammatory cytokines produced by the macrophages. In addition, by measuring quercetin release behavior, we determined the optimum type and molecular weight of the film coating polymer for the effective suppression of inflammation. These results suggest that the incorporation and controlled release of quercetin could be a promising method to reduce inflammation induced by PLA films.

KW - Anti-inflammatory

KW - Antioxidant

KW - Controlled release

KW - Implantation

KW - PLA film

UR - https://www.scopus.com/pages/publications/84953304106

U2 - 10.7317/pk.2015.39.6.934

DO - 10.7317/pk.2015.39.6.934

M3 - Article

AN - SCOPUS:84953304106

SN - 0379-153X

VL - 39

SP - 934

EP - 939

JO - Polymer (Korea)

JF - Polymer (Korea)

IS - 6

ER -

Inhibitory effects of an antioxidant coating on a polylactic acid film on inflammatory cytokines from macrophage

Abstract

Keywords

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