Inhibitory effects of cultivated wild ginseng on the diff erentiation of 3T3-L1 Pre-adipocytes

Mohammad Lalmoddin Mollah; Yong Pil Cheon; Jun Gyo In; Deok Chun Yang; Young Chul Kim; Jae Chan Song; Kil Soo Kim

doi:10.5142/jgr.2011.35.1.045

Inhibitory effects of cultivated wild ginseng on the diff erentiation of 3T3-L1 Pre-adipocytes

Mohammad Lalmoddin Mollah, Yong Pil Cheon, Jun Gyo In, Deok Chun Yang, Young Chul Kim, Jae Chan Song, Kil Soo Kim

Department of Veterinary Medicine

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Wild ginseng has been used as a traditional medicine for thousands of years and for increase physical strength in Korea, China and Japan. This study reports that cultivated wild ginseng (CWG) inhibits adipocyte differentiation of 3T3-L1 preadipocytes in a concentration-dependent manner. Inhibition of adipocyte differentiation is one possible anti-obesity strategy. CWG inhibits the expression of the adipocyte differentiation regulator peroxisome proliferators-activated receptor (PPAR)γ and CCAAT/enhancer-binding protein α mRNA. It also inhibited the expression of PPARγ and adiponectin at the protein level during the differentiation of pre-adipocytes into adipocytes. Additionally, CWG blocked the cell cycle at the sub-G1 phase transition, causing cells to remain in the pre-adipocyte state. These results indicate that CWG inhibits adipocyte differentiation and adipogenesis through pre-adipocyte cell cycle arrest in cultured 3T3-L1 cells.

Original language	English
Pages (from-to)	45-51
Number of pages	7
Journal	Journal of Ginseng Research
Volume	35
Issue number	1
DOIs	https://doi.org/10.5142/jgr.2011.35.1.045
State	Published - 2011

Keywords

3T3-l1 cells
Adipocyte differentiation
Adipogenesis
Cell cycle arrest
Cultivated wild ginseng
Panax ginseng

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.5142/jgr.2011.35.1.045

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title = "Inhibitory effects of cultivated wild ginseng on the diff erentiation of 3T3-L1 Pre-adipocytes",

abstract = "Wild ginseng has been used as a traditional medicine for thousands of years and for increase physical strength in Korea, China and Japan. This study reports that cultivated wild ginseng (CWG) inhibits adipocyte differentiation of 3T3-L1 preadipocytes in a concentration-dependent manner. Inhibition of adipocyte differentiation is one possible anti-obesity strategy. CWG inhibits the expression of the adipocyte differentiation regulator peroxisome proliferators-activated receptor (PPAR)γ and CCAAT/enhancer-binding protein α mRNA. It also inhibited the expression of PPARγ and adiponectin at the protein level during the differentiation of pre-adipocytes into adipocytes. Additionally, CWG blocked the cell cycle at the sub-G1 phase transition, causing cells to remain in the pre-adipocyte state. These results indicate that CWG inhibits adipocyte differentiation and adipogenesis through pre-adipocyte cell cycle arrest in cultured 3T3-L1 cells.",

keywords = "3T3-l1 cells, Adipocyte differentiation, Adipogenesis, Cell cycle arrest, Cultivated wild ginseng, Panax ginseng",

author = "Mollah, {Mohammad Lalmoddin} and Cheon, {Yong Pil} and In, {Jun Gyo} and Yang, {Deok Chun} and Kim, {Young Chul} and Song, {Jae Chan} and Kim, {Kil Soo}",

year = "2011",

doi = "10.5142/jgr.2011.35.1.045",

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journal = "Journal of Ginseng Research",

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AU - Mollah, Mohammad Lalmoddin

AU - Cheon, Yong Pil

AU - In, Jun Gyo

AU - Yang, Deok Chun

AU - Kim, Young Chul

AU - Song, Jae Chan

AU - Kim, Kil Soo

PY - 2011

Y1 - 2011

N2 - Wild ginseng has been used as a traditional medicine for thousands of years and for increase physical strength in Korea, China and Japan. This study reports that cultivated wild ginseng (CWG) inhibits adipocyte differentiation of 3T3-L1 preadipocytes in a concentration-dependent manner. Inhibition of adipocyte differentiation is one possible anti-obesity strategy. CWG inhibits the expression of the adipocyte differentiation regulator peroxisome proliferators-activated receptor (PPAR)γ and CCAAT/enhancer-binding protein α mRNA. It also inhibited the expression of PPARγ and adiponectin at the protein level during the differentiation of pre-adipocytes into adipocytes. Additionally, CWG blocked the cell cycle at the sub-G1 phase transition, causing cells to remain in the pre-adipocyte state. These results indicate that CWG inhibits adipocyte differentiation and adipogenesis through pre-adipocyte cell cycle arrest in cultured 3T3-L1 cells.

AB - Wild ginseng has been used as a traditional medicine for thousands of years and for increase physical strength in Korea, China and Japan. This study reports that cultivated wild ginseng (CWG) inhibits adipocyte differentiation of 3T3-L1 preadipocytes in a concentration-dependent manner. Inhibition of adipocyte differentiation is one possible anti-obesity strategy. CWG inhibits the expression of the adipocyte differentiation regulator peroxisome proliferators-activated receptor (PPAR)γ and CCAAT/enhancer-binding protein α mRNA. It also inhibited the expression of PPARγ and adiponectin at the protein level during the differentiation of pre-adipocytes into adipocytes. Additionally, CWG blocked the cell cycle at the sub-G1 phase transition, causing cells to remain in the pre-adipocyte state. These results indicate that CWG inhibits adipocyte differentiation and adipogenesis through pre-adipocyte cell cycle arrest in cultured 3T3-L1 cells.

KW - 3T3-l1 cells

KW - Adipocyte differentiation

KW - Adipogenesis

KW - Cell cycle arrest

KW - Cultivated wild ginseng

KW - Panax ginseng

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Inhibitory effects of cultivated wild ginseng on the diff erentiation of 3T3-L1 Pre-adipocytes

Abstract

Keywords

UN SDGs

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